Diphenyl compounds which inhibit arachidonic acid metabolism, an

Details Diphenyl compounds which inhibit arachidonic acid metabolism, an Diphenyl compounds which inhibit arachidonic acid metabolism, an

1991-09-04

1993-02-09

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ether doai

514712, 514735, 514826, 514863, 514946, A61K 31075

Patent

active

051853779

ABSTRACT:
Pharmaceutical compositions, which comprise a compound of the general formula I ##STR1## in which X is oxygen, sulfur or -CH.sub.2 -, Y is chlorine or bromine, Z is an SO.sub.2 H, NO.sub.2 or C.sub.1 -C.sub.4 alkyl radical, r is a number from 0 to 3, o is a number from 0 to 3, p is the number 0 or 1, m is the number 1 or 2 and n is the number 0 or 1, have having a lipoxygenase- and prostaglandin H synthase-inhibiting action.
The compositions are useful in particular for the local (topical) or inhalative treatment of inflammatory, allergic and spasmolytic diseases, as well as psoriasis, bronchial asthma and diseases with disturbances in cell proliferation.

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