Diol-containing renin inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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Details

544106, 544383, 560 9, 564 79, A61K 3702

Patent

active

050360531

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, composition containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertensions, or hyperaldosteronism.

REFERENCES:
patent: 4845079 (1989-07-01), Luly et al.
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Denkewalter et al., Progress in Drug Research. 1966, vol. 10, pp. 510-512.
Plattner et al., J. Med. Chem., 1988, 31(12), 2277-2288.

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