Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-18
2007-12-18
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S251000, C548S252000, C548S253000, C548S255000, C514S359000, C514S374000, C514S381000, C514S616000, C564S153000
Reexamination Certificate
active
11070733
ABSTRACT:
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
REFERENCES:
patent: 98/12213 (1998-03-01), None
Xu et al, Biochemistry, 2003, 42, 8696-8703.
Carter et al., Chemotherapy of Cancer, second edition, John Wiley & Sons, N.Y., N.Y., 1981, pp. 362-365.
De Brabander Jef K.
Harran Patrick G.
Li Lin
Suzuki Hidetaka
Thomas Ranny Mathew
Board of Regents , The University of Texas System
Kumar Shailendra
Osman Richard Aron
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