Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-15
2006-08-15
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S263000, C544S319000, C544S237000, C544S123000, C514S274000, C540S523000
Reexamination Certificate
active
07091209
ABSTRACT:
A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme
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patent: WO 92/05159 (1992-04-01), None
patent: 19817265 (1998-04-01), None
patent: WO 00/13708 (2000-03-01), None
Roberts et al. “Basic principles of Organic Chemistry” (Benjamin, INC 1964) p. 531.
Methyl 2-(4-chlorophenyl)-5,6-dihydroxyprimidine-4-carboxylate, 1999 Maybridge plc catalog.
T. P. Culbertson, “Synthesis of 5,6-Dihydroxy-2-phenyl-4-pyrimidinecarbxylic Acid, Methyl Ester, a Corrected Structure,” J. Heterocyclic Chem., 1979, vol. 16, pp. 1423-1424.
A. A. Santilli et al., “Synthesis of 1,2,4-Oxadiazines and Their Rearrangement to Pyrimidines”, J. Heterocyclic Chem., 1979, vol. 16, pp. 213-216.
Translation of Claims of WO 92/05159.
Gardelli Cristina
Giuliano Claudio
Harper Steven
Koch Uwe
Narjes Frank
Berch Mark L.
Merck & Co. , Inc.
Walton K. R.
Winokur M.
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