Dibenzosuberanyl piperazine derivatives and drug-resistance...

Details Dibenzosuberanyl piperazine derivatives and drug-resistance... Dibenzosuberanyl piperazine derivatives and drug-resistance...

2005-04-19

2005-04-19

Pryor, Alton (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

06881841

ABSTRACT:
Dibenzosuberanyl piperazine derivatives represented by the following formula (I):wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof.These compounds show effectiveness in allowing resistance-acquired causes of diseases to restore sensitivity to drug, that is, a resistance overcoming effect.

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David F. Tang-Wai et al.: “Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators” Biochemistry, vol. 34, No. 1, pp. 32-39, 1995.

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