Dibenzodiazepine derivatives, their preparation and use

Details Dibenzodiazepine derivatives, their preparation and use Dibenzodiazepine derivatives, their preparation and use

2006-04-11

2006-04-11

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S494000, C540S555000

Reexamination Certificate

active

07026311

ABSTRACT:
The invention relates to compounds of the formula Iand their tautomeric forms, possible enantiomeric and diastereomeric forms and their prodrugs, and to their preparation and use, where A, B, R1and X1have the meanings given in the description.

REFERENCES:
patent: WO 01/16136 (2001-03-01), None
patent: WO 01/23390 (2001-04-01), None
Breslin et al., Synthesis and Anti-HIV-1 Activity of 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) Derivatives, Journal of Medicinal Chemistry, vol. 38, No. 5, pp. 771-793, Mar. 1995.
Burkle, Physiology and Pathophysiology of Poly(ADP-ribosyl)ation, BioEssays, vol. 23, No. 9, pp. 795-806, Sep. 2001.
Burkart, et al., Mice lacking the poly (ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozcin; Mar. 1999, pp. 314-319; vol. 5, No. 3, Nature Medicine.
Chen, et al., Potentiation of the antitumor activity of cisplatin in mice by 3-aminobenzamide and nicotinamide; (1998), pp. 303-307; vol. 22, Cancer Chemotherapy and Pharmacology.
Ehrlich, et al., Inhibition of the induction of collagenase by interleukin 1β in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobensamide; Mar. 1995, pp. 171-172; vol. 15; Rheumatol Int.
Gäken, et al., Efficient Retroviral Infection of Mammalian Cells Is Blocked by Inhibition of Poly (ADP-Ribose) Polymerase Activity; Jun. 1996; pp. 3992-4000; vol. 70, No. 6; Journal of Virology.
Cuzzocrea, et al., Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occulosion and reperfusion; 1997; pp. 1065-1074; vol. 121; British Journal of Pharmacology.
Cuzzocrea, et al., Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation; 1998, pp. 67-76; vol. 342; European Journal of Pharmacology.
Ikai, et al., Immunohistochemical Demonstration of Poly (Adenosine Diphosphate-Ribose) Synthetase in Bovine Tissues; 1983; pp. 1261-1264; vol. 31, No. 11; The Hournal of Histochemistry and Cytochemistry.
Kröger, et al., Synergistic Effects of Thalidomide and Poly(ADP-Ribose) Polymerase Inhibition on Type II Collagen-Induced Arthritis in Mice; 1996; pp. 203-215;vol. 20, No. 2; Inflammation.
Shall, Sydney; ADP-Ribose in DNA Repair; A New Component of DNA Excision Repair; 1984; pp. 1-65; vol. II, Advances in Radiation Biology.
Kameoka, et al., Poly (ADP-ribose) Polymerase Is Involved in PMA-induced Activation of HIV-1 in U1 Cells by Modulating the LTR Function; 1999; pp. 285-289; vol. 262; Biochemical and Biophysical Research Communications.
Satoh, et al., Role of poly(ADP-ribose) formation of DNA repair; Mar. 1992; pp. 356-358; vol. 356; Nature.
Szabó, et al., Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase; Mar. 1998; 3867-3872; vol. 95; Proc. Natl. Acad. Sci. USA.
Weltin, et al., Immunosuppressive Activities of 6(5H)-Phenanthridinone, A New Poly (ADP-Ribose) Polymerase Inhibitor; 1995; pp. 265-271, vol. 17, No. 4; Int. J. Immunopharmac.
Thiemermann, et al., Inhibition of the activity of poly (ADP ribose) synthetase reduces ischemia -reperfusion injury in the heart and skeletal muscle; Jan. 1997; pp. 679-683; vol. 94; Proc. Natl. Acad. Sci. USA.

Affiliated with

Also associated with

Rating

Dibenzodiazepine derivatives, their preparation and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dibenzodiazepine derivatives, their preparation and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dibenzodiazepine derivatives, their preparation and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3531606