Dibenzo[a,g]quinolizinium derivatives and the salts thereof

Details Dibenzo[a,g]quinolizinium derivatives and the salts thereof Dibenzo[a,g]quinolizinium derivatives and the salts thereof

1999-01-22

2000-02-22

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 71, 544333, C07D21520, C07D491147

Patent

active

060281979

ABSTRACT:
The present invention provides a 5,6-dihydrodibenzo[a,g]quinolizinium derivative and the salts thereof of formula (I) which specifically inhibits the sterol 14-reductase which is involved in the distal pathway of cholesterol biosynthesis, and the use of the compound of formula (I) for treating hypercholesterolaemia or hyperlipidaemia. ##STR1## wherein, R.sup.1 and R.sup.2 which may be the same or different from each other, represent a hydroxy group or an alkoxy group having 1 to 4 carbons or R.sup.1 and R.sup.2 together represent a methylenedioxy group;

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