Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-06-27
2006-06-27
Richter, Johann (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S665000, C514S009100, C530S317000, C540S467000, C564S500000
Reexamination Certificate
active
07067508
ABSTRACT:
The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a preparative kit of the composition for treating liver cancer.In the composition according to the invention, the diaminedithiol derivative is a novel compound in which long chain alkyl groups were introduced to diaminedithiol, capable of forming a radiorhenium or radiotechnetium complex thereof with an ease and leading to stronger van der Waals bonds with lipiodol. As a result, the complex becomes more stable in a medium, lipiodol, whereby the composition of the invention exhibits a high accumulation rate in liver cancer tissue when injected via hepatic artery, thereby capable of achieving an efficient treatment of liver cancer.
REFERENCES:
patent: 5095111 (1992-03-01), Lever et al.
patent: 5196515 (1993-03-01), Lever et al.
patent: 5496533 (1996-03-01), Jackson et al.
Chung June-Key
Jeong Jae Min
Kim Young Ju
Lee Dong Soo
Lee Myung Chul
Bachman & LaPointe P.C.
Nwaonicha Chukwuma
Richter Johann
Seoul National University Industry Foundation
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