Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-12-18
1987-06-02
Marantz, Sidney
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4351722, 435240, 435948, 436529, 436531, 436548, 436811, 530387, 530808, 530813, 530815, 935104, 935108, 935110, G01N 33545, G01N 33569, G01N 33577
Patent
active
046703845
ABSTRACT:
A hybrid cell formed by the fusion of a mouse spleen cell with a mouse myeloma cell secretes an IgM class antibody. The antibody is useful as a preparative reagent in the isolation of three proteins, molecular weights 45,000, 49,000 and 53,000, from the parasite Trichinella spiralis and is also useful as a direct diagnostic reagent is a competitive serodiagnostic test.
REFERENCES:
patent: 4468346 (1984-08-01), Paul et al.
H. R. Gamble et al., American Journal of Veterinary Research 45, 67-74, 1984.
H. R. Gamble et al., Veterinary Immunology and Immunopathology 6, 379-389, 1984.
D. S. Silberstein et al. Journal of Immunology 132, 898-904, 1984.
G. Galfre et al., Methods in Enzymology 73, 3-46, 1981.
V. Mazzola, "New Trichinosis Test--First Step to Eradication," Agricultural Research, p. 10 (Jun. 1984).
V. Mazzola, "Monoclonal Antibodies: Probing the Mysteries of Immunity," and Monoclonal Antibodies at Work, Agricultural Research, pp. 8-11, (Jan. 1984).
H. R. Gamble, "Application of Hybridoma Technology to the Diagnosis of Parasitic Disease," handed out at Second International Immunoparasitology Symposium, Aug. 3-5, 1983.
H. R. Gamble, "Application of Hybridoma Technology to the Diagnosis of Parasitic Disease, Veterinary Parasitology 14: 251-261 (1984).
E. J. Ruitenberg, P. A. Steerenberg, B. J. M. Brosi, and J. Buys, "Reliability of the Enzyme-Linked Immunosorbent Assay (ELISA) for the Serodiagnosis of Trichinella spiralis Infections in Conventionally Raised Pigs," Journal of Immunological Methods 10: 67-83 (1976).
H. R. Gamble, W. R. Anderson, C. E. Graham, and K. D. Murrell, "Diagnosis of Swine Trichinosis by Enzyme-Linked Immunosorbent Assay (ELISA) Using an Excretory-Secretory Antigen," Veterinary Parasitology 13: 349-361 (1983).
G. L. Seawright, D. Despommier, W. Zimmerman, and R. S. Isenstein, "Enzyme Immunoassay for Swine Trichinellosis Using Antigens Purified by Immunoaffinity Chromatography," Am. J. Trop. Med. Hyg. 32(6): 1275-1284 (1983).
F. VanKnapen, J. H. Franchimont, N. Skovgaard, J. Guidal, and S. A. Henriksen, "Husbandry, Parasitic and Other Diseases as Factors in the Reliability of the Enzyme-Linked Immunosorbent Assay (ELISA) for Detection of Trichinellosis in Pigs," Veterinary Parasitology 16: 17-22 (1984).
M. K. Showe, E. Isobe, and L. Onorato, "Bacteriophage T4 Prehead Proteinase," J. Mol. Biol. 107: 55-69 (1976).
Gamble Howard R.
Murrell Kenneth D.
Connor Margaret A.
Marantz Sidney
Saunders David A.
Scott William E.
Silverstein M. Howard
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