Diagnostic and therapeutic use of antibodies against the...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C424S133100, C424S135100, C424S138100, C530S300000

Reexamination Certificate

active

07399468

ABSTRACT:
The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.

REFERENCES:
patent: 5234816 (1993-08-01), Terstappen
patent: 5519120 (1996-05-01), Dano et al.
patent: 5530101 (1996-06-01), Queen et al.
patent: 5747654 (1998-05-01), Pastan et al.
patent: 6638502 (2003-10-01), Li et al.
patent: 0 317 156 (1989-05-01), None
patent: 0 608 987 (1994-08-01), None
patent: WO 94 99363 (1994-04-01), None
McHugh et al., J. Immuno Methods 1986 95:57-61.
Tockman et al., Cancer Research, vol. 52, p. 2711s (1992).
Janicke et al, Fibrinolysis vol. 4, p. 69 (1990).
W. Xue et al.: Urokinase-type plasminogen activator receptors associate with betal and beta 3 integrins of fibrosarcoma cells: dependence on extracellular matrix components: Cancer Research, vol. 57, No. 9, May 1, 1997, pp. 1682-1689, XP002117246, Baltimore, MD, VSA abstract; figure 1.
T. Luther et al.: “Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue” American Journal of Pathology, vol. 150, No. 4, Apr. 1997, pp. 1231-1244, XP002117251,Hagerstown, MD, USA, cited in the whole document.
R. Todd et al.: “CD87 Workshop Panel report (pp. 1016-1020 in ‘Leucocyte Typing VI’, Eds. T. Kishimoto et al.)” 1997, Garland Publishing, Inc. XP002117252 Cited in the application, figures, tables.
V. Magdolen et al.: “Epitope-mapped monoclonal antibodies directed to the human urokinase receptor (uPAR, CD87).” Tissue Antigens, vol. 48, No. 4-2, Oct. 1996, p. 424 XP000929590, Kopenhagen, Dänemark, Abstract MC-2-02.
K. Fischer et al.: “Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function.” Febs Letters, vol. 438, No. 1-2,Oct. 30, 1998, pp. 101-105, XP002143814, Amsterdam, die Niederland, Abstract, figure 3.
H. Allgayer et al.: “Immunocytochemical phenotyping of disseminated tumor cells in bone marrow by uPA and receptor and CK18: investigation of sensivity and specificity of an immunogold/alkaline phosphatase double staining protocol” Journal of Histochemistry and Cytochemistry, vol. 45, No. 2, Feb. 1997, Baltimore, MD, USA cited in the application abstract.
M. Heiss et al.: “individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: a reference to early systemic disease in solid cancer” Nature Medicine, vol. 1, No. 10, Oct. 1995, pp. 1035-1039, XP02117248 New York, NY, USA cited in the application p. 1039, col. 1, line 18, paragraph 2—line 39.
I. Funke et al..: “comparative analyses of bone marrow micrometastases in breast and gastric cancer” International Journal of Cancer, vol. 65, No. 6, Mar. 15, 1996, pp. 755-761, XP002117249 New York, NY, USA cited in the application abstract.
R. Ciccocioppo et al.: “Detection of the receptor for the human urokinase-type fluoresceinated uPA” Journal of Histochemistry and Cytochemistry, vol. 45, No. 9, Sep. 1997, Baltimore, MD, USA cited in the application figures 1, 2.
Fundamental Immunology 242 (William E. Paul, M.D. ed., 3d ed. 1993).
Rudikoff et al (Proc Natl Acad Sci USA 1982 vol. 79 p. 1979.

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