Diagnosis and treatment of TKA-1 related disorders

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 2431, 435 691, 4352523, 43525411, 4353201, 435325, 435194, C12N 1512

Patent

active

059455233

ABSTRACT:
The present invention relates to TKA-1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for TKA-1 related diseases or conditions characterized by an abnormal interaction between a TKA-1 polypeptide and a TKA-1 binding partner.

REFERENCES:
patent: 4945050 (1990-07-01), Sanford et al.
Sambrook et al., Molecular Cloning, A Lab. Manual, 2nd Ed., 16.2-16.30, 1-17.28, Cold Spring Harbor Lab. Press. 1989.
Hillier et al., "yp07h01.r1 Homo sapiens cDNA clone 186769 5' similar to H51921, Sep. 18, 1995.
Castellanos and Mazon, "Identification of Phosphotyrosine in Yeast Proteins and of a Protein Tyrosine Kinase Associated with the Plasma Membrane," J. Biol. Chem. 260(14):8240-8242 (1985).
Maness, "Nonreceptor Protein Tyrosine Kinases Associated with Neuronal Development," Dev. Neurosci. 14:257-270 (1992).
Seedorf et al., "TKA-1, a novel type of cellular tyrosine kinase binding protein, selectively activates the platelet-derived growth factor receptor signaling potential," EMBL Database Entry HSTKA1MR, Accession No. Z50150, XP002023872 (Apr. 1, 1996).
Weinmann et al., "Characterization of a Protein Cofactor That Mediates Protein Kinase A Regulation of the Renal Brush Border Membrane Na.sup.+ --H.sup.+ Exchanger," Journal of Clinical Investigation 95:2143-2149 (1995).
Margolis et al., "EGF Induces Tyrosine Phosphorylation of Phospholipase C-II: A Potential Mechanism for EGF Receptor Signaling," Cell 57:1101-1107 (1989).
Mayer et al., "A Novel viral oncogene with structural similarity to phospholipase C," Nature 332:272-275 (Mar. 1988).
McKnight, "Functional Relationships between Transcriptional Control Signals of the Thymidine Kinase Gene of Herpes Simplex Virus," Cell 31:355-365 (1982).
Miller, "Human gene therapy comes of age," Nature 357:455-460 (1992).
Miller et al., "Generation of Helper-Free Amphotropic Retroviruses That Transduce a Dominant-Acting, Metotrexate-Resistant Dihydrofolate Reductase Gene," Molecular Cell Biology 5:431-437 (1985).
Mulligan, "The Basic Science of Gene Therapy," Science 260:926-932 (1993).
Nelson et al., "Detection of Acridinium Esters by Chemiluminescence," Nonisotopic DNA Probe Techniques ed. L.J. Kricka (San Diego:Academic Press, Inc. pp. 275-310 (1992).
Nishibe et al., "Increase of the Catalytic Activity of Phospholipase C-.gamma.1 by Tyrosine Phosphorylation," Science 250:1253-1256 (1990).
Pawson and Schlessinger, "SH2 and SH3 domains," Current Biology 3(7):434-441 (1993).
Pawson and Gish, "SH2 and SH3 Domains: From Structure to Function," Cell 71:359-362 (1992).
Ponting and Phillips, "DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins," TIBS 20:102-103 (1995).
Posada and Cooper, "Molecular Signal Integration. Interplay Between Serine, threonine and Tyrosine Phosphorylation," Mol. Biol. of the Cell 3:583-592 (1992).
Pursel et al., "Genetic Engineering of Livestock," Science 244:1281-1288 (1989).
Ridley and Hall, "The Small GTP-Binding Protein rho Regulates the Assembly of Focal Adhesions and Actin Stress Fibers in Response to Growth Factors," Cell 70:389-399 (1992).
Ridley et al., "The Small GTP-Binding Protein rac Regulates Growth Factor-Induced Membrane Ruffling," Cell 70:401-410 (1992).
Ronnstrand et al., "Characterization of Two Monoclonal Antibodies Reactive with the External Domain of the Platelet-derived Growth Factor Receptor," J. Biol. Chem. 263(21):10429-10425.
Sadowski et al., A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130.sup.gag-fps, Mol. and Cell. Biol. 6(12):4396-4408 (1986).
Schlessinger and Ullrich, "Growth Factor Signalling by Receptor Tyrosine Kinases," Neuron 9:383-391 (1992).
Schlessinger, "Signal transduction by allosteric receptor oligomerization,"Trends Biochem. Sci. 13:443-447 (1988).
Seedorf et al., "Analysis of Platelet-derived Growth Factor Receptor Domain Function Using a Novel Chimeric Receptor Approach," J. Biol. Chem. 266:12424-12431 (1991).
Seedorf et al., "Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates," Molecular Cell Biology 12:4347-4356 (1992).
Silver et al., "Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization," Proc. Natl. Acad. Sci. USA 81:5951-5955 (1984).
Snyder, "No endothelial NO," Nature 377:196-197 (1995).
Ullrich and Schlessinger, "Signal Transduction by Receptors with Tyrosine Kinase Activity," Cell 61:203-212 (1990).
van der Geer and Pawson, "The PTB domain: a new protein module implicated in signal transduction," TIBS 20:277-280 (1995).
Weinman et al., "Camp-mediated Inhibition of the Renal Brush Border membrane Na.sup.+ -H.sup.+0 Exchanger Requires a Dissociable Phosphoprotein Cofactor," Jrnl Clinical Investigation 92:1781-1786 (1993).
Weinman et al., "Characterization of a Protein Cofactor That Mediates Protein Kinase A Regulation of the Renal Brush Border Membrane Na.sup.+ -H.sup.+ Exchange," Jrnl Clinical Investigation 95:2143-2149 (1995).
Yang et al., "In Vivo and In Vitro Gene Transfer to Mammalian Somatic Cells by Particle Bombardment," Proc. Natl. Acad. Sci. USA 87:9568-9572 (1990).
Yarden and Ullrich, "Growth factor receptor tyrosine kinase," Ann. Rev. Biochem. 57:443-478 (1988).
Gottesman, "Bacterial Regulation: Global Regulatory Networks," Ann. Rev. Genet. 18:415-441 (1984).
Hamer and Walling, "Regulation In Vivo of a Cloned Mammalian Gene: Cadmium Induces the Transcription of a Mouse Metallothionein Gene in SV40 Vectors," J. of Molecular and Applied Genetics 1:273-288 (1982).
Hammer et al., "Spontaneous Inflammatory Disease in Transgenic Rats Expressing HLA-B27 and Human .beta..sub.2 m: An Animal Model of HLA-B27-Associated Human Disorders," Cell 63:1099-1112 (1990).
Hardie, "Roles of Protein Kinases and Phosphatases in Signal Transduction," Symp. Soc. Exp. Bio. 44:241-255 (1990).
Heinemann and Hahn, "Circular permutations of protein sequence: not so rare" TIBS 20:349-350 (1995).
Herbst et al., "Substrate Phosphorylation Specificity of the Human c-kit Receptor Tyrosine Kinase," J. of Biol. Chem. 266(30):19908-19916 (1991).
Honegger et al., "Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation," Proc. Natl. Acad. Sci. USA 86:925-929 (1989).
Houdebine and Chourrout, "Transgenesis in Fish," Experientia 47:891-897 (1991).
Huang et al., "Hypertension in mice lacking the gene for endothelial nitric oxide synthase," Nature 377:239-242 (1995).
Johnston and Hopper, "Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon," Proc. Natl. Acad. Sci. USA 79:6971-6975 (1982).
Joyner et al., "Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells," Nature 338:153-156 (1989).
Kim et al., "PDGF Stimulation of Inositol Phospholipid Hydrolysis Requires PLC-V.gamma.1 Phosphorylation on Tyrosine Residues 783 and 1254, " Cell 65:435-441 (1991).
Klingensmith et al., "The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal, " Genes & Development 8:118-130 (1994).
Koch et al., "SH2 and SH3 Domains: Elements That Control Interactions of Cytoplasmic Signaling Proteins," Science 252:668-674 (1991).
Koonin et al., "dlg-R proteins: modified guanylate kinases," Nature Genetics 2:256-257 (1992).
Kornau et al., "Domain Interactions Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95," Science 269:1737-1740 (1995).
Kris et al., "Antibodies against a Synthetic Peptide as a Probe for the Kinase Activity of the Avian EGF Receptor and v-erbB Protein," Cell 40:619-625 (1985).
Lee et al., "HER2 cytoplasmic domain generates normal mitogeni

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diagnosis and treatment of TKA-1 related disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnosis and treatment of TKA-1 related disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnosis and treatment of TKA-1 related disorders will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2426727

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.