Process for the chemical synthesis of oligonucleotides

Details Process for the chemical synthesis of oligonucleotides Process for the chemical synthesis of oligonucleotides

1995-06-07

1999-08-31

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2531, 536 2534, 536 271, 536 2721, 536 2761, 536 2762, 536 2763, 536 278, 536 2854, C07H 100, C07H 3170

Patent

active

059455241

ABSTRACT:
Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes.
The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.

REFERENCES:
patent: 3781310 (1973-12-01), Meininger et al.
E. Winnacker, "From Genes to Clones," 1987, Chaoter 2.3.
C. Lehmann et al., "Solid-phase synthesis of oligoribonucleotides using 9-fluorenylmethoxycarbonyl (Fmoc) for 5'-hydroxyl protection," Nucleic Acid Research, vol. 17, No. 7, 2379-2390, Apr. 1989.

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