Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-12-07
2010-12-07
Bowman, Amy (Department: 1635)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024310, C536S024330
Reexamination Certificate
active
07846664
ABSTRACT:
The present invention provides diagnostic methods and kits for diagnosis of chronic lymphocytic leukemia (CLL) by determining expression levels of isoforms of cyclic nucleotide phosphodiesterases (PDEs) associated with CLL particularly, PDE7B and/or PDE3B, and a ratio of mRNA expression of PDE7B to PDE3B. The present invention provides that CLL lymphocytes uniformly expressed high levels of PDE7B and low levels of PDE3B relative to those of normal lymphocytes. A method of treatment and a pharmaceutical composition for CLL comprising one or more therapeutic agents capable of modulating expression or activity levels of isoforms of PDEs associated with CLL, and/or reversing the ratio of PDE7B/PDE3B mRNA expression levels are also provided.
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patent: 6849638 (2005-02-01), Stolle et al.
patent: 2004/0018513 (2004-01-01), Downing et al.
Moon et al., 2002, “Inhibition of PDE3B Augments PDE4 Inhibitor-Induced Apoptosis in a Subset of Patients with Chronic Lymphocytic Leukemia,” Clinical Cancer Research, vol. 8, 589-595.
Insel Paul A.
Kanter Joan R.
Kipps Thomas
Murray Fiona
Rassenti Laura
Bowman Amy
Sutherland & Asbill & Brennan LLP
The Regents of the University of California
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