Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2011-01-04
2011-01-04
Hutson, Richard G (Department: 1652)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C435S007100, C435S193000, C435S069200, C530S387100, C530S388100, C530S387900, C424S130100, C424S141100
Reexamination Certificate
active
07862819
ABSTRACT:
Nucleic acid compositions encoding mammalian DGAT2α polypeptide products with diglyceride acyltransferase activity, as well as the mammalian DGAT2α polypeptide products encoded thereby and methods for producing the same, are provided. The subject DGAT2α polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.
REFERENCES:
patent: 6100077 (2000-08-01), Sturley et al.
patent: 2003/0170691 (2003-09-01), Rosana et al.
patent: WO 98/55631 (1998-12-01), None
patent: WO 99/67268 (1999-12-01), None
patent: WO 99/67403 (1999-12-01), None
patent: WO 00/01713 (2000-01-01), None
patent: WO 00/05367 (2000-02-01), None
patent: WO 00/12708 (2000-03-01), None
patent: WO 00/12708 (2000-03-01), None
patent: WO 00/32756 (2000-06-01), None
patent: WO 00/32756 (2000-06-01), None
patent: WO 00/32793 (2000-06-01), None
patent: WO 00/32793 (2000-06-01), None
patent: WO 00/36114 (2000-06-01), None
patent: WO 99/47655 (2000-09-01), None
patent: WO 00/60095 (2000-10-01), None
patent: WO 00/60095 (2000-10-01), None
patent: WO 00/66749 (2000-11-01), None
Ngo et al., Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Zhu et al., Niacin inhibits activity of Diacylglycerol acyltransferase (DGAT), a key enzyme for Triglyceride synthesis in HEPG2 Cells, Journal of Investigative Medicine, vol. 48, No. 2, pp. 206A, Mar. 2000.
Ganji et al., “Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells”, Journal of Lipid Research, vol. 45, pp. 1835-1845, 2004.
Cases et al. (1998) “Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.”Proc. Natl. Acad. Sci. USA, vol. 95:13018-13023.
Oelkers et al. (1998) “Characterization of Two Human Genes Encoding Acyl Coenzyme A: Cholesterol Acyltransferase-related Enzymes.”J. Biol. Chem., vol. 273(41):26765-26771.
Smith et al. (2000) “Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.”Nature Genetics, vol. 25:87-90.
Database EMBL Online! EBI, Dec. 1, 2001, “Diacylglycerol acytransferase 2 (hypothetical protein)”, retrieved from EMBL, Database accession No. Q96PD7, XP002285959, see sequence.
Database EMBL Online! EBI; Oct. 8, 2001, “Homo sapiensdiacylglycerol O-acyltransferase homolog 2 (mouse), mRNA, (cDNA clone MGC: 17861 IMAGE:3903313)” retrieved from EMBL Database accession No. BC015234, XP002285960, see sequence.
Database EMBL Online! EBI; Jun. 1, 2001, “0610010B06Rik protein (Diacylglycerol acyltransferase 2”) retrieved from EMBL, Database accession No. Q9DCV3, XP002285961.
Farese, Robert V. Jr. et al., “Triglyceride synthesis: Insights from the cloning of diacylglycerol acyltransferase” Current Opinion in Lipidology, vol. 11, No. 3, Jun. 2000, pp. 229-234.
Cases, S et al. “Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members” Journal of Biological Chemistry, American Society of Biological Chemists, Baltimore, MD, US, vol. 276, No. 42, Oct. 19, 2001 , pp. 38870-38876, XP002199715.
Lehner, Richard et al., “Biosynthesis of triacylglycerols” Progress in Lipid Research, Pergamon Press, Paris, FR, vol. 35, No. 2, 1996, pp. 169, 201a, XP002262929, ISSN: 0163-7827, the whole document, in particular, pp. 179-190.
Database EMBL EBI; Feb. 9, 2001. “Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4933405B12 product:diacylglyerol o-acyltransferase 2, full insert sequence.” retrieved from EMBL accession No. AKO16660.
Database EMBL [Onine] Feb. 8, 2001, “Musmusculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610010B06 product:diacylglycerol O-acyltransferase 2, full insert sequence.” retrieved from EBI accession No. EMBL:AK002443 Database accession No. AK002443.
Cases Sylvaine
Farese Robert V.
Stone Scot J.
Zhou Ping
Borden Paula A.
Bozicevic Field & Francis LLP
Hutson Richard G
The J. David Gladstone Institutes
LandOfFree
Diacylglycerol O-acyltransferase 2α (DGAT2α) does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diacylglycerol O-acyltransferase 2α (DGAT2α), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diacylglycerol O-acyltransferase 2α (DGAT2α) will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2714943