Device for the capture of target molecules, and capturing proces

Details Device for the capture of target molecules, and capturing proces Device for the capture of target molecules, and capturing proces

1994-06-24

1998-03-03

Hutzell, Paula K.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

422 57, 435 6, 435 71, 435 75, 435 792, 435 794, 4352872, 4352879, 435975, 436524, 436528, 436531, 436532, 436534, 436807, G01N 33543, G01N 33544, C12Q 168

Patent

active

057233446

ABSTRACT:
Device for capturing a target molecule for the purpose of detecting it and/or assaying it, including a solid support on which is immobilized a ligand, the ligand being provided in the form of a conjugate resulting from the covalent coupling of a polymer with a plurality of molecules of the ligand. The polymer is an N-vinylpyrrolidone copolymer, and the conjugate is immobilized on the solid support by adsorption.
When the ligand is capable of forming a complex with the target, the device is specific for a given target. When the device comprises, in addition, a bifunctional reagent capable of forming a complex, on the one hand, with the ligand and, on the other hand, with the target, the support on which the ligand is immobilized constitutes a universal capturing system.

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Gray, 1979. Elisa methodology for polysaccharide antigens: protein coupling of polysaccharides for adsorption to plastic tubes. J. Immunolog. Meth. 28: 187-192.

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