Determination of glycosilated hemoglobin

Details Determination of glycosilated hemoglobin Determination of glycosilated hemoglobin

1982-09-29

1984-03-20

Marantz, Sidney

Chemistry: analytical and immunological testing

Hemoglobin, myoglobin, or occult blood

Glycosylated hemoglobin

436 17, G01N 3372, G01N 3366

Patent

active

044382049

ABSTRACT:
A process for the determination of glycosilated hemoglobin in a blood sample comprises liberating glycosilated and non-glycosilated hemoglobin from the erythrocytes by chemical or physical treatment; converting, if desired, the hemoglobin into methemoglobin, and thereafter differentiating the glycosilated and non-glycosilated hemoglobin portion using its reaction with haptoglobin, and determining the glycosilated and/or the non-glycosilated hemoglobin portion.
The present invention also provides a reagent for the determination of glycosilated hemoglobin in a blood sample, as well as a reagent for the differentiation of glycosilated and non-glycosilated hemoglobin, comprising haptoglobin.

REFERENCES:
patent: 4189304 (1980-02-01), Adams
patent: 4200435 (1980-04-01), Stroupe
patent: 4255385 (1981-03-01), Stroupe
patent: 4371374 (1983-02-01), Cerami

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