Desulfatohirudins, the preparation thereof and pharmaceutical co

Details Desulfatohirudins, the preparation thereof and pharmaceutical co Desulfatohirudins, the preparation thereof and pharmaceutical co

1986-11-13

1988-05-17

Shapiro, Lionel M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

514 12, C07K 710, A61K 3743, A61K 3702

Patent

active

047451777

ABSTRACT:
The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof.
The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.

REFERENCES:
patent: 4668662 (1987-05-01), Tripier
Dodt et al., FEBS Lett, vol. 165, No. 2, pp. 180-184 (Jan. 1984).
Walsmann et al, Die Pharmazie, 36: pp. 653-660 (1981).
P. D. Boyer, The Enzymes, 3rd Ed. Academic Press, New York, vol. 5, pp. 21-41 (1971).

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