Derivatives of kanamycin A

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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536 10, 536 17R, A61K 3171, C07H 1522

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active

041706420

ABSTRACT:
Novel derivatives of kanamycin, 1-N-(L-4-amino-2-hydroxy butyryl)-6'-N-alkylkanamycins, have been prepared which possess improved antibacterial activity against gram-positive and gram-negative bacteria including kanamycin-resistant strains.

REFERENCES:
patent: 3781268 (1973-12-01), Kawaguchi et al.
patent: 4001208 (1977-01-01), Umezawa et al.
Umezawa et et al., "The Journal of Antibiotics", vol. XXV, No. 12, pp. 743-745, 1972.

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