Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-10-13
1997-01-07
Woodward, Michael P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 8, 530317, 530322, 530323, A61K 3812, A61K 3814, C07K 900
Patent
active
055917143
ABSTRACT:
New N-alkyl and N-acyl derivatives of A82846A, A82846B, A82846C and PA-42867-A are provided. The new glycopeptide derivatives are useful for the treatment of susceptible bacterial infections, especially infections due to Gram-positive microorganisms.
REFERENCES:
patent: 4552701 (1985-11-01), Nagarajan et al.
patent: 4639433 (1987-01-01), Hunt et al.
patent: 4643987 (1987-02-01), Nagarajan et al.
patent: 4698327 (1987-10-01), Nagarajan et al.
patent: 4946941 (1990-08-01), Kondo et al.
E. N. Olsufyeva et al., Antibiotics and Chemotherpy, 34, 352-358 (May 1989).
Centers for Disease Control and Prevention, "Nosocomial Enterococci Resistant to Vancomycin--United States, 1989-1993", MMWR Morbid Mortal Wkly Rep, 42:597-599 (1993).
Richard V. Spera, Jr., and Bruce F. Farber, "Multiply-Resistant Enterococcus Faecium--the Nosocomial Pathogen of the 1990s", JAMA 268(18):2563-2564 (Nov. 11, 1992).
Richard V. Spera, Jr., and Bruce F. Farber, "Multidrug-Resistant Enterococcus Faecium--an Untreatable Nosocomial Pathogen", Drugs 48(5):678-688 (1994).
J. Clin. Microbiol., 26:1216-1218 (1988). "Recovery of Resistant Enterococci during Vancomycin prophylaxis", Kaplan, A. et al.
Antimicrob. Agents Chemother., 33:198-203 (1989). Schlaes et al., "Inducible Transferable Resistance to Vancomycin in Enterococcus faecalis A256".
Ramakrishnan Nagarajan, "Structural Activity Relationships of Vancomycin and Related Antibiotics", 28th Intersci. Conf. Antimicrob. Agents Chemother., Oct. 23-26, 1988.
Kondo et al., Chemical Abstract, vol. 107, No. 196526w (1987).
Hamill et al., Chemical Abstract, vol. 111, No. 76518f (1989).
Leclercq, et al., N. Engl. J. Med., 319, 157-161 (1988).
Assandri, et al., Eur J Clin Pharmacol, 33, 191-195 (1987).
Nicas, et al., Antimicrobial Agents and Chemotherapy, 33, 1477-1481 (1989).
Wick, et al., Journal of Bacteriology, 81, 233-235 (1961).
Moellering, et al., Reviews of Infectious Diseases, 3, S230-S235 (1981).
Uttley, et al., The Lancet, 1, 57-58 (1988).
Nagarajan, et al., J. Org. Chem., 54, 983-986 (1989).
Nagarajan, et al., J. of Antibiotics, 41, 1430-1438 (1988).
Nagarajan, et al., J. of Antibiotics, 42, 63-72 (1989).
Nagarajan Ramakrishnan
Schabel Amelia A.
Eli Lilly and Company
Jones Joseph A.
Leeds James P.
Page Kathleen R. S.
Prickril Benet
LandOfFree
Derivatives of A82846 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of A82846, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of A82846 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1764115