Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2007-04-24
2007-04-24
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S106000, C435S128000, C435S069100, C536S023200
Reexamination Certificate
active
10508356
ABSTRACT:
The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable enzyme, particularly a suitable amine oxidase, and for the generation of novel enzymes suitable for use in the deracemisation method.
REFERENCES:
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Geha, Rani Maurice et al., “Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid,”Journal of Biological Chemistry, vol. 276, No. 13, Mar. 30, 2001, pp. 9877-9882.
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Alexeeva Marina Victorovna
Enright Alexis
Mahmoudian Mahmoud
Turner Nicholas
Campen Virginia G.
Glaxo Group Limited
Meah M. Y.
Prouty Rebecca E.
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