Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-01-21
1998-05-12
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530300, 530326, 530328, 514 2, 930 10, C07K 14705
Patent
active
057506523
ABSTRACT:
The present invention relates to amino acid sequences of the encoded deltex protein. The invention further relates to fragments and other derivatives, and analogs, of deltex proteins. In specific embodiments, the invention relates to deltex protein derivatives and analogs of the invention which are functionally active, or which comprise one or more domains of a deltex protein, including but not limited to the Gln-rich clusters, SH3 binding domains, domains which mediate binding to Notch or to a Notch derivative containing Notch cdc10/SW16/ankyrin ("ANK") repeats, domains which mediate binding to a second deltex protein, or any combination of the foregoing. The present invention also relates to compositions based on deltex proteins.
REFERENCES:
Duboule et al "DNA Sequences Homologous to the Drosophila Opa Repeat . . . " Mol. Cell. Biol. 7(5):2003-2006 (May 1987).
Peterson et al "Functional Domains and Upstream Activation Properties of Cloned Human TATA Binding Protein", Science 248:1625-1630 (Jun. 1990).
Karson et al., 1992, "Prospect for human gene therapy," J. Reproductive Medicine 37(6):508-514.
Roemer and Friedmann, 1992, "Concepts and strategies for human gene therapy," Eur. J. Biochem. 208:211-225.
Uhlmann and Peyman, 1990, "Antisense oligonucleotides: a new therapeutic principle" Chemical Reviews 90(4):544-584.
Artavanis-Tsakonas and Simpson, 1991, "Choosing a cell fate: a view from the Notch locus," Trends Genet. 7:403-408.
Artavanis-Tsakonas et al., 1991, "The Notch locus and the cell biology of neuroblast segregation," Ann. Rev. Cell Biol. 7:427-452.
Bennett, 1992, J. Biol. Chem. "Adaptors between diverse plasma membrane proteins and the cytoplasm," 267:8703-8706.
Blank et al., 1992, "NF-.kappa.B and related proteins: rel/dorsal homologies meet ankyrin-like repeats," Trends Biochem. Sci. 17:135-140.
Breeden and Nasmyth, 1987, "Similarity between cell-cycle genes of budding yeast and fisson yeast and the Notchl gene of Drosophila, "Nature 329:651-654.
Bunch et al., 1988, "Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells,", Nucl. Acids Res. 16:1043-1061.
Burns et al., 1984, "Isolation and characterization of cloned DNA sequences containing ribosomal protein genes of Drosophila melanogaster, " Mol. Cell. Biol. 4:2643-4652.
Cagan and Ready, "Notch is required for successive cell decisions in the developing Drosophilaretina," Genes Dev. 3:1099-1112.
Chirgwin et al. 1979, "Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease," Biochemisty 18:5294-5299.
Coffman et al., 1990, "Xotch, the Xenopus homolog of Drosophila notch, " Science 249:1438-1441.
Coffman et al, 1993, "Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos," Cell 73:659-671.
Delidakis et al., 1991, "Two genetically and molecularly distinct functions involved in early neurogenesis reside with the Enhancer of split locus of Drosophila melanogaster, " Genetics 129:803-823.
Demerec et al., 11942, "The gene," Yearbook-Carnegie Institution 41:190-199.
Ellisen et al, 1991, "TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms," Cell 66:649-661.
Fehon et al., 1990, "Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila," Cell 61:523-534.
Fehon et al., 1991, "Complex cellular and subcellular regulation of Notch expression during embryonic and imaginal development of Drosophila: implications for Notch function," J. Cell Biol. 113:657-669.
Feinberg and Vogelstein, 1984, "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity," Anal. Biochem. 137:266-267.
Fortini and Artavanis-Tsakonas, 1993, "Notch: neurogensis is only part of the picture," Cell 75:1245-1247.
Fortini et al, 1993, "An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye," Nature 365:555-557.
Foster, 1975, "Negative complementation at the Notch locus of Drosophila melanogaster, " Genetics 81:99-120.
Franco del Amo et al., 1992, "Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development," Development 115:737-744.
Franco del Amo et al., 1993, "Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch, " Genomics 15:259-264.
Frischauf et al., 1983, "Lambda replacement vectors carrying polylinker sequences," J. Biol. 170:827-842.
Geiser et al., 1992, "cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IKB gene family of vertebrates," Cell 71:613-621.
Gietz et al., "Improved method for high efficiency transformation of intact yeast cells," Nucl. Acids Res. 20:1425.
Golubovsky, 1983, "Recessive sex-linked female-specific lethals at deltex locus discovered in natural populations of D. melanogaster," Dros. Inf. Ser. 59:42-43.
Gorman and Girton, 1992, "A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster, " Genetics 131:99-112.
Hartley et al., 1987, "The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein," EMBO J. 6:3407-3417.
Hartley et al., 1988, "A deduced gene product from the Drosophila neurogenic locus, Enhancer of split, shows homology to mammalian G-protein .beta. subunit," Cell 55:785-795.
Heitzler and Simpson, 1991, "The choice of cell fate in the epidermis of Drosophila," Cell 64:1083-1092.
Heitzler and Simpson, 1993, "Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions," Development 117:1113-1123.
Hultmark et al., 1986, "Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22, " Cell 44:429-438.
Kelley et al., 1987, "Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus," Cell 51:539-548.
Kidd et al., 1986, "Sequence of the Notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors," Mol. Cell. Biol. 6:3094-3108.
Kidd, 1992, "Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins," Cell 71:623-635.
Klambt et al., 1989, "Closely related transcripts encoded by the neurogenic gene complex Enhancer of split of Drosophila melanogaster, " EMBO J. 8:203-210.
Knust et al., 1987, "Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster, " EMBO J. 6:4113-4123.
Koch et al., 1991, "SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins," Science 252:668-674.
Kodoyianni et al., 1992, "Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabitis elegans, " Molec. Biol. Cell 3:1199-1213.
Kongsuwan et al., 1985, "A Drosophila Minute gene encodes a ribosomal protein," Nature 317:555-558.
Kopan and Weintraub, 1993, "Mouse Notch: expression in hair follicles correlates with cell fate determination," J. Cell Biol. 121:631-641.
LaMarco et al., 1991, "Identification of Ets-and Notch-related subunits in GA binding protein," Science 253:789-792.
Lefevre, 1974, "The one-band gene hypothesis: evidence from a cytogenetic analysis of mutant and nonmutant rearrangement breakpoints in Drosophila melanogaster, " Cold Spring Harbor Symp. Quant. Biol. 38:591-599.
Lux et al., 1990, "Analysis of cDNa for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins," Nature 344:36-42.
Maine et al., 1985, "The sex-lethal gene of Drosophila: DNA alterations associated with sex-specific letal mutations," Cell 43:521-529.
McGinnis et al., 1984, "A conserved DNA sequence in homoeotic genes of the Drosophila antennapedia and bithorax complexes," Nature 308:428-433.
Michaely and Bennett, 1992, "The
Artavanis-Tsakonas Spyridon
Busseau Isabelle
Diederich Robert J.
Matsuno Kenji
Xu Tian
Sorensen Kenneth A.
Walsh Stephen
Yale University
LandOfFree
Deltex proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Deltex proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Deltex proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-980047