Deletion and substitution analogues of melittin peptide

Details Deletion and substitution analogues of melittin peptide Deletion and substitution analogues of melittin peptide

1991-01-22

1993-08-10

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530858, A61K 3702, C07K 710

Patent

active

052350380

ABSTRACT:
A compound comprising an analogue of the melittin peptide having the following structural formula: ##STR1## wherein at least one and no more than four amino acid residues are omitted from the peptide, or at least one of amino acid residues 1-6, 8-18, or 20-26 in the peptide is substituted with a hydrophobic residue, provided that no more than two of amino acid residues 21-26 is substituted with a hydrophobic residue. Such deletion and substitution analogues are useful as antibiotics, antimicrobial agents, antifungal agents, anti-tumor agents, antiviral agents, or agents which stimulate wound healing.

REFERENCES:
patent: 4810777 (1989-03-01), Zasloff
patent: 4822608 (1989-04-01), Benton et al.
patent: 4962277 (1990-10-01), Cuervo et al.
Dayhoff, Atlas of Protein Sequence and Structure 1972 vol. 5, Nat. Biomed. Res. Found, p. 96.
Kreil, "The Structure of Apis Dorsata Melittin: Phylogenetic Relationships between Honeybees . . . ", FEBS Lett. 54(1), Jun. 1975, pp. 100-102.
Wade et al, "All-amino acid-containing channel-forming antibiotic peptides," PNAS USA 87, Jun. 1990, pp. 4761-4765.

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