Use of kainic acid antagonists to prevent toxic side effects of

Details Use of kainic acid antagonists to prevent toxic side effects of Use of kainic acid antagonists to prevent toxic side effects of

1995-03-20

1998-06-16

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142262, 514280, 514282, 514318, 514646, A61K 31445, A61K 3154, A61K 3144, A61K 31135

Patent

active

057671303

ABSTRACT:
This invention discloses that kainic acid receptor antagonists (KA antagonists) can act as "safener" agents to reduce or prevent adverse side effects caused by NMDA antagonists. NMDA antagonists can reduce excitotoxic brain damage due to stroke, cardiac arrest, asphyxia, etc., but they also cause toxic damage to certain types of neurons, as well as psychotomimetic effects such as hallucinations. Co-administration of a KA antagonist can (1) reduce or prevent such undesired side effects, and (2) increase the extent of neuronal protection provided to the CNS, beyond the levels of protection that can be provided by NMDA antagonists alone, or non-NMDA antagonists alone. Therefore, co-administration of a KA antagonist allows NMDA antagonists to be used more safely and effectively.

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