DDAVP antidiuretic and method therefor

Details DDAVP antidiuretic and method therefor DDAVP antidiuretic and method therefor

1985-12-17

1991-09-10

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514807, A61K 3734

Patent

active

050473980

ABSTRACT:
There is disclosed, in one aspect, an antidiuretic composition in oral dosage form for humans. This composition comprises an antidiuretically effective amount of 1-deamino-8-D-arginine vasopressin (DDAVP) and a pharmaceutically acceptable carrier. The composition is capable of dissolving and being absorbed in the gastrointestinal tract of a human. The composition isused in tablet, capsule, or other generally accepted oral dosage form and generally from about 50 to about 200 micrograms of DDAVP is used per unit dosage In another aspect, there is disclosed a method for treating diabetes insipidus. This method comprises orally administering an antidiuretically effective amount of DDAVP to a human. The DDAVP is substantially dissolved and absorbed in the gastrointestinal tract of the person so treated.

REFERENCES:
patent: 3454549 (1969-07-01), Boissonnas
patent: 3497491 (1970-02-01), Zaoral
Kinter et al, cited in Chem. Abstracts, vol. 97:193479x 1982.
American Heritage Dictionary 2nd ed p. 924.
Remingtons Pharm. Sciences 15th Ed. (1975) pp. 83 & 84.

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