Process for selective removal of salivary .alpha.-amylase and as

Details Process for selective removal of salivary .alpha.-amylase and as Process for selective removal of salivary .alpha.-amylase and as

1991-11-15

1996-11-19

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435810, 435961, 435962, 436526, 436539, 436823, 436824, 53038826, 5303911, 530413, G01N 33573

Patent

active

055761810

ABSTRACT:
Inter alia, a process for the selective removal of salivary .alpha.-amylase from a sample comprising salivary .alpha.-amylase and pancreatic .alpha.-amylase characterized in that there is used a monoclonal antibody against salivary .alpha.-amylase, which is immobilized or is coupled to a physically separable or seperate support and which exhibits a binding affinity towards salivary .alpha.-amylase of at elast 1.times.10.sup.7 l/m and a cross-reactivity with pancreatic .alpha.-amylase of less than 1% is disclosed. The remaining pancreatic .alpha.-amylase may be assayed.

REFERENCES:
patent: 4554088 (1985-11-01), Whitehead et al.
patent: 4939082 (1990-07-01), Naujoks et al.
Mifflin, T. E. et al, "Rapid Quantitative, Specific Measurement of Pancreatic Amylase in Serum with Use of a Monoclonal Antibody", Clin. Chem. 31(8) pp. 1283-1288, 1985.
Bruns, D. E. et al, "Appendix: Production and Characterization of a Monoclonal Antibody to Distinguish Human Pancreatic and Salivary Amylase", Clin. Chem. 31(8) pp. 1286-1288, 1985.
Gerber, M. et al, "A Monoclonal Antibody That Specifically Inhibits Human Salivary .alpha.-Amylase", Clin. Chem. 33(7) pp. 1158-1162, 1987.
Ito, K. et al, "Preparation of Human Salivary .alpha.-Amylase Specific Monoclonal Antibody", J. Biochem. 97(5) pp. 1357-1362, 1985.
Hiroishi, S. et al, "Differnetial Assay of Salivary and Pancreatic .alpha.-Amylase in Serum and Urine, with Use of Monoclonal Antibody to Human Salivary Amylase Immobilized on Bacterial Cell Wall", Cli. Chem. 33(7) pp. 1235-1236, 1987.

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