Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-10-30
2000-02-01
Myers, Carla J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 2431, 536 2433, 435 6, C07H 2104, C12Q 168
Patent
active
060204761
ABSTRACT:
A small family of novel genes referred to as the DAZ gene family, present in interval 6D and/or 6E of the distal portion of the long arm of the human Y chromosome and on human chromosome 3. Alteration of a DAZ gene present in interval 6D and/or 6E of the distal portion of the long arm of the human Y chromosome is associated with reduced sperm count. Methods of diagnosis and treatment utilizing a DAZ gene, and antibodies that bind to the protein encoded by said genes.
REFERENCES:
patent: 5695935 (1997-12-01), Page et al.
patent: 5776682 (1998-07-01), First et al.
patent: 5840549 (1998-11-01), First et al.
patent: 5871920 (1999-02-01), Page et al.
Foote et al. Science 258: 60-66, 1992.
Lucotte et al. Nucleic Acids Research 13:8285, 1985.
Yen et al. Human Molecular Genetics 5: 2013-2017 (abstract provided), 1996.
Kun Ma et al., "A Y Chromosome Gene Family with RNA-Binding Protein Homology: Candidates for the Azoospermia Factor AZF Controlling Human Spermatogenesis", Cell 75:1287-1295 (1993).
Simon Foote et al., "The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region", Science 258:60-66 (1992).
Douglas Vollrath et al., "The Human Y Chromosome: A 43-Interval Map Based on Naturally Occurring Deletions", Science 258:52-59 (1992).
Renee Reijo et al., "Mouse Autosomal Homolog of DAZ, a Candidate Male Sterility Gene in Humans, Is Expressed in Male Germ Cells before and after Puberty", Genomics 35:346-352 (1996).
Howard J. Cooke et al., "A murine homologue of the human DAZ gene is autosomal and expressed only in male and femal gonads", Hum. Molec. Genet. 5(4) :513-516 (1996).
Kim Yen Ngo et al., "A DNA Probe Detecting Multiple Haplotypes of the Human Y Chromosome", Am. J. Hum. Genet. 38:407-418 (1996).
G. Lucotte et al., "Y Chromosome DNA Polymorphisms in Two African Populations", Am. J. Hum. Genet. 45:16-20 (1989).
Renee Reijo et al., "Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene", Nature Genet. 10:383-393 (1995).
P.H. Vogt et al., "Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11", Hum. Mole. Genet 5(7):933-943 (1996).
Colin Bishop et al., "Extensive Sequence Homologies Between Y and Other Human Chromosomes", J. Mol. Biol. 173:403-417 (1984).
Gerad Lucotte et al., "Nucleotide sequence of p49a, a genomic Y-specific probe with potential utilization in sex determination", Molec. and Cell. Probes 5:359-363 (1991).
Hawkins Trevor
Page David C.
Reeve Mary Pat
Reijo Renee
Saxena Richa
Myers Carla J.
Whitehead Institute for Biomedical Research
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