DAZ: a gene associated with azoospermia

Details DAZ: a gene associated with azoospermia DAZ: a gene associated with azoospermia

1994-09-22

1997-12-09

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 231, 536 235, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

056959354

ABSTRACT:
Novel gene present in interval 6E and/or 6D of the distal portion of the long arm of the human Y chromosome, whose alteration is associated with reduced sperm count. Methods of diagnosis and treatment utilizing said gene, and antibodies that bind to the protein encoded by said gene.

REFERENCES:
Ma, K et al, Towards a molecular localization of the AZF locus; mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromosome, Hum. Mol. Genetic 1(1)29-33, 1992.
Ma, Kun et al., "A Y Chromosome Gene Family With RNA-Binding Protein Homology: Candidates for the Azoospermia Factor AZF Controlling Human Spermatogenesis", Cell, 75:1287-1295, (Dec. 31, 1993).
Foote, Simon et al., "The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region", Science, 258:60-66, (Oct. 2, 1992).
Vollrath, Douglas et al., "The Human Y Chromosome: A 43-Interval Map Based on Naturally Occurring Deletions", Science, 258:52-59, (Oct. 2, 1992).

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