Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1996-12-03
1998-07-28
Carlson, Karen
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435195, C12N 900, C12N 914
Patent
active
057861900
ABSTRACT:
The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.
REFERENCES:
Dickens et al., Jour. of Bacteriology, vol. 178 No. 11, "Isolation and Characterization of a Gene from Streptomyces sp. Strain C5 That confers the Ability to Convert Daunomycin to Doxorubicin on Streptomyces lividans TK24", pp. 3389-3395, 1996.
Columbo et al, Expression of Doxorubicin-Daunorubcin Resistance Genes in Different Anthracycline-producing Muants of Streptomyces peucetius; 1992 J. Bacteriology 174 (5); pp. 1641-1646.
Otten et al, Cloning and characterization of the Streptomyces peucetius dnrQS Genes Encoding a Daunosamine Biosynthesis Enzyme and a Glycosyl Transferase Involved in Daunorubicin Biosynthesis; 1995, J. Bacteriol 177 (22); pp. 6668-6692.
Otten et al, 1990, Cloning and Expression of Daunorubicin Biosynthesis Genes from Strpetomyces peucetius and S. peucetius subsp. caesius; J. Bacteriol 172 (6); pp. 3427-3434.
Breme Umberto
Colombo Anna Luisa
Hutchinson Charles Richard
Inventi Augusto Solari
Otten Sharee
Carlson Karen
Pharmacia & Upjohn S.p.A.
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