D-Homopregnanes

Details D-Homopregnanes D-Homopregnanes

1978-12-26

1980-05-13

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424331, 424308, 560107, 560257, 568372, C07C 4900, C07J 6300

Patent

active

042028418

ABSTRACT:
D-Homopregnanes of the formula ##STR1## wherein the dotted line in the 1,2-position together with the corresponding solid line denotes a single or double carbon-carbon bond; R.sup.6 is hydrogen, fluoro, chloro or methyl; R.sup.9 is hydrogen, fluoro, chloro or bromo; R.sup.11 is hydroxyl, acyloxy, fluoro or chloro; and R.sup.17a is hydroxyl or acyloxy with the proviso that when R.sup.9 is fluoro, chloro or bromo and R.sup.11 is fluoro or chloro, the atomic number of R.sup.11 is less than or equal to that of R.sup.9 ; and with the further proviso that when R.sup.6 is hydrogen, and R.sup.11 and R.sup.17a are hydroxy or when R.sup.6 is fluoro, R.sup.11 and R.sup.17a are hydroxyl and the dotted line in the 1,2-position together with the corresponding solid line denotes a single carbon-carbon bond, R.sup.9 is fluoro, chloro or bromo and processes for the preparation thereof are disclosed.

REFERENCES:
patent: 2860158 (1958-11-01), Clinton
patent: 3939193 (1976-02-01), Alig et al.
patent: 4026918 (1977-05-01), Furst et al.
patent: 4026923 (1977-05-01), Alig et al.

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