Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1974-11-29
1977-08-30
Schwartz, Gerald A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260400, 260405, 260456R, 260456P, 260473A, 260476C, 260483, 260586E, 424308, 424311, 424312, 424313, 424331, A01N 914, A61K 31255, C07C 4926
Patent
active
040455742
ABSTRACT:
D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is oxygen, ##STR2## in which R.sub.5 is hydrogen or lower acyl; R.sub.2 is hydrogen or methyl; R.sub.3 is oxygen, ##STR3## or two hydrogen atoms; R.sub.4 is hydrogen, hydroxy or acyloxy; R.sub.6 is hydrogen or methyl; and R.sub.7 is hydrogen, acetyl, hydroxy or lower acyloxy in the .alpha.- or .beta.-position possess CNS-depressant activity, including anesthesia upon parenteral administration, and are produced by hydrogenating the corresponding steroids having double bonded C.sub.5 and/or C.sub.16 carbon atoms.
REFERENCES:
patent: 2860158 (1958-11-01), Clinton
patent: 3686223 (1972-08-01), Miller
patent: 3833621 (1974-09-01), Grunwell et al.
Horowski Reinhard
Kehr Wolfgang
Kerb Ulrich
Kieslich Klaus
Palenschat Dieter
Schering Aktiengesellschaft
Schwartz Gerald A.
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