Procedure for the manufacture of 3-amino-2-oxo-pyrrolidines, new

Details Procedure for the manufacture of 3-amino-2-oxo-pyrrolidines, new Procedure for the manufacture of 3-amino-2-oxo-pyrrolidines, new

1999-09-10

2000-12-05

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562556, 562559, C07D20740, C07D31500, C07D32100

Patent

active

061569089

ABSTRACT:
The invention is directed to a process for the preparation of lactams of Formula I. It is further directed to new advantageous intermediates of Formula II and the use thereof. By the cyclization of compounds of Formula II, compounds of Formula I are obtained.

REFERENCES:
patent: 5484946 (1996-01-01), Abood et al.
German Patent Office communication dated Sep. 15, 1998.
"Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides", 1982 Amer. Chem. Soc., pp. 104-198, vol. 47, No. 1.
"Decrease of a-Helix Potential and Biological Activity of b-Endorphin in Response to Modifications of MET.sup.5 ", Neuropeptides : 47-51, 1980.
Methiomine Studies VII, May, 1945, pp. 849-851,Toennies, et al, 1945.
"Preparation of D-,DL, and L-Homoserine Lactone from Methionine", Microchem. Journal, 40, 226-232 (1989).
"The Reaction of Idoacetate with Methionine", Journal of Biol. Chem. vol. 234, No. 7, Jul. 1959, pp. 1761-1765.

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