Cytoxic substances from the marine cyanophyte hormothamnion ente

Details Cytoxic substances from the marine cyanophyte hormothamnion ente Cytoxic substances from the marine cyanophyte hormothamnion ente

1989-03-06

1990-06-19

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31122

Patent

active

049355295

ABSTRACT:
Several new, biologically active substances have been isolated from Hormothamnion enteromorphoides, a somewhat rare cyanophyte from Puerto Rico.
Hormothamnion, a lipophilic metabolite from this alga, has the styrylchromone structure: ##STR1## Hormothamnion and, to a lesser extent, one of its homologs, are potent cytotoxins to some types of cancer cells and appear to exert this cytotoxic action by a selective inhibition of RNA synthesis.
A peptide compound of about 11 to 12 amino acids has antimicrobial activity, particularly against Candida albicans. The peptide, which includes phenylalanine, serine and other aliphatic amino acids, has blocked carboxyl and amino termini.

REFERENCES:
patent: 4281008 (1981-07-01), Chamberlain et al.
Gerwick et al., C.A. 105, 75478g (1986).
Alonso et al., Tetrahedron Letters, 29, 735-738 (1988).
Suffness et al., J. Nat. Prod. 45, 1-14 (1982) .

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