Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
1999-06-01
2001-06-26
Kifle, Bruck (Department: 1611)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S461000
Reexamination Certificate
active
06251885
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to cytotrienins I, II, III and IV, a process for preparing the same and anti-tumor agents containing the same as the active ingredient.
2. Description of the Background
Recent studies have demonstrated that many oncogene products act as signal transduction molecules and activation of such products induces neoplasia of cells. A number of oncogene products have been identified and it has now become clear that more than 50% of oncogenes encode tyrosine kinase, and these oncogenes are closely related to malignant transformation of cells and to retention of cancer morphology. Thus, it is considered that a compound which inhibits the functions of these oncogene products might be a potential anti-tumor agent and, hence, there is a need for additional anti-tumor agents having such a mode of action.
In addition, although many anti-tumor compounds have already been developed, a need still exists for additional anti-tumor agents having a new and different chemical structure.
SUMMARY OF THE INVENTION
Accordingly, it is an object of the present invention to provide compounds having anti-tumor activity, i.e., cytotrienins I, II, III and IV, a preparation method for the same and anti-tumor agents containing the same as the active ingredient.
REFERENCES:
patent: 5686606 (1997-11-01), Mizukami et al.
patent: WO98/23594 (1998-04-01), None
Patent Abstracts of Japan, vol. 14, No. 137 (C-0702), Mar. 15, 1990, JP 02-011573, Jan. 16, 1990.
Patent Abstracts of Japan, vol. 7, No. 191 (C-182), Aug. 20, 1983, JP 58-094393, Jun. 4, 1983.
Tetrahedron Letters (1997) vol. 38, No. 10, P. 1789-1792, “Novel Triene-ansamycins, Cytotrienins A and B, Inducing Apoptosis on Human Leukemia HL-60 Cells”, Hui-ping Zhang et al.
The journal of Antibiotics (1997) vol. 50, No. 4, p. 370-372, “Cytotrienin A, a Novel Apoptosis Inducer in Human Leukemia HL-60 Cells,” Hideaki Kakeya et al.
The Journal of Antibiotics (1993) vol. 46, No. 11, p. 1678-1686, “Novel Cytocidal Compounds, Oxopropalines from Streptomyces s. G324 producing Lavendamycin”, , Naoki Abe et al.
The Journal of Antibiotics (1981) vol. 34, No. 11, P. 1402-1407, “Fredericamycin A. A New Antitumor Antibiotic”, Dana J. Warnick-Pickle et al.
Kakeya Hideaki
Kobinata Kimie
Osada Hiroyuki
Zhang Hui-ping
Kifle Bruck
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
The Institute of Physical and Chemical Research
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