Cytotoxic protein and utilization thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C435S810000

Reexamination Certificate

active

07385035

ABSTRACT:
This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced byHelicobacter pyloriand the use.This invention provides a cytotoxic protein (M toxin) produced byHelicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.

REFERENCES:
patent: 4800155 (1989-01-01), Taniguchi et al.
patent: 5024946 (1991-06-01), Abe et al.
patent: 5093261 (1992-03-01), Hagiwara et al.
patent: 5366865 (1994-11-01), Gralnick
patent: 5776427 (1998-07-01), Thorpe et al.
patent: 5863538 (1999-01-01), Thorpe et al.
patent: 5877289 (1999-03-01), Thorpe et al.
patent: 6004555 (1999-12-01), Thorpe et al.
patent: 6093399 (2000-07-01), Thorpe et al.
patent: 6417337 (2002-07-01), Anderson et al.
patent: 6753420 (2004-06-01), Anderson et al.
patent: 6787153 (2004-09-01), Hosokawa et al.
patent: 6887474 (2005-05-01), Stewart et al.
patent: 2002/0061569 (2002-05-01), Haselbeck et al.
patent: WO 97/37044 (1997-10-01), None
U.S. Appl. No. 11/049,118, filed Oct. 2005, Awdalla.
U.S. Appl. No. 11/149,515, filed Dec. 2005, Nichols et al.
U.S. Appl. No. 11/205,045, filed Dec. 2005, Stewart et al.
Brown, J. M. “Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies.” Molecular Medicine Today Apr. 2000 (vol. 6).
Paganelli G, Riva P, Deleide G, et al,In vivo labelling of biotinylated monoclonal antibodies by radioactive avidin: a strategy to increase tumor radiolocalization, Int J Cancer Suppl. 1988; 2: 121-125.
P. Webber et al., “Structural origins of high-affinity biotin binding to streptavidin” Science, vol. 243, pp. 85-88, Jan. 6, 1989.
M. Wilchek et al, The avidin-biotin complex in bioanalytical applications Analytical Biochemistry, vol. 171 pp. 1-32, 1988.
Bayer et al., “The Avidin-Biotin Complex as a Tool in Molecular Biology”, Trends in Biochemical Science, 3, N257, Nov. 1978.
Otto C. Boerman et al., “Pretargeted Radioimmunotherapy of Cancer: Progress Step by Step”, Journal of Nuclear Medicine vol. 44 No. 3 400-411.
Kohler and Milstein, Nature, 256: 495-97, 1975; Eur. J. Immunol., 6: 511-19, 1976.
Hechler, B., Leon, C., Vial, C., Vigne, P., Frelin, C., Cazenave, J. P., and Gachet, C. (1998) Blood 92, 152-159.
Duijvestijn et al., “Lymphoid Tissue- and Inflammation-Specific Endothelial Cell Differentiation defined by Monoclonal Antibodies,” The Journal of Immunology, 138(3):713-719, 1987.
Hagemeier et al., “A Monoclonal Antibody Reacting with Endothelial Cells of Budding Vessels in Tumors and Inflammatory Tissues, and Non-Reactive with Normal Adult Tissues,” International Journal of Cancer, 38:481-488, 1986.
Bruland et al., “New Monoclonal Antibodies Specific for Human Sarcomas,” International Journal of Cancer, 38:27-31, 1986.
Murray et al., “Vascular Markers for Murine Tumours,” Radiotherapy and Oncology, 16:221-234, 1989.
Schlingemann et al., “Monoclonal Antibody PAL-E Specific for Endothelium,” Laboratory Investigation, 52(1):71-76, 1985.
Shrestha et. al., Eur. J. Cancer B. Oral. Oncol., 30B(6):393-9, 1994.
Tuominen and Kallioinen, J. Cutan. Pathol. 21(5):424-9, 1994.
American Cancer Society: Cancer Facts and Figures 2005.

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