Cys-Ser-Val-Thr-Cys-Gly specific tumor cell adhesion receptor

Details Cys-Ser-Val-Thr-Cys-Gly specific tumor cell adhesion receptor Cys-Ser-Val-Thr-Cys-Gly specific tumor cell adhesion receptor

1992-05-14

1994-11-22

Wityshyn, Michael G.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

530350, C07K 1514

Patent

active

053670590

ABSTRACT:
The present invention provides a cell matrix receptor specific for the Cys Ser Val Thr Cys Gly (SEQ ID NO: 1) region of thrombospondin. Also provided are purification, cloning and expression methods. Antibodies directed against the receptor protein are useful in numerous diagnostic, prophylactic and therapeutic areas.

REFERENCES:
patent: 5190920 (1993-03-01), Eyal et al.
patent: 5192744 (1993-03-01), Bouck et al.
Asch et al., "Isolation of Thrombospondin Membrane Receptor", J Clin Invest., vol. 79, 1987 pp. 1054-1061.
Asch et al., "Thrombospondin sequence motif . . . ", Biochem & Biophy. Commun., vol. 182, No. 3, Feb. 1992, pp. 1208-1217.
Yabkowitz, et al., "Human Carcinoma Cells . . . ", Cancer Research, vol. 51, Jul. 1991, pp. 3648-3656.
Yabkowitz et al, "Human Carcinoma Cells Express Receptors . . . " Cancer Research, vol. 51, Mar. 1991, pp. 1645-1650.
McGregor, et al., "Rapid Purification & Partial Characterization . . . " J of Biol. Chem., vol. 264, No. 1, 1989, pp. 501-506.

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