Cyclophanes, pharmaceutical compositions containing these compou

Details Cyclophanes, pharmaceutical compositions containing these compou Cyclophanes, pharmaceutical compositions containing these compou

1991-03-28

1992-09-15

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546203, 546204, 548528, 544294, 544105, 540609, 564230, 564305, A61K 31445, C07D21106

Patent

active

051478820

ABSTRACT:
Cyclophanes of the general formula ##STR1## wherein X.sub.1, X.sub.2, A, R and R.sub.1 to R.sub.4 are as defined herein, the enantiomers, diastereomers and addition salts thereof and, more particularly, for pharmaceutical use, the physiologically acceptable addition salts thereof, which have pharmacological properties such as lowering blood pressure, dilating the coronary blood vessels and a mild heart rate lowering activity, pharmaceutical compositions which contain these compounds and processes for preparing them.

REFERENCES:
Upjohn Co., "Therapeutically active . . . ", CA 63: 9892d (1965).
Burger et al., "Certain physiologically . . . ", CA 62: 11750h (1965).
Hagishita et al., "Synthesis and absolute . . . ", Chem. Pharm. Bull. 24 (8) 1724-1730 (1976).

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