Cyclopentabenzofuran derivatives and their use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S444000, C514S464000, C514S468000, C546S284100, C549S060000, C549S078000, C549S435000, C549S458000, C549S466000

Reexamination Certificate

active

06943182

ABSTRACT:
The invention relates to cyclopentabenzofuran derivatives, process for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-κB-dependent diseases and medicaments which contain the cyclopentabenzofuran derivatives.

REFERENCES:
patent: 4539414 (1985-09-01), King et al.
patent: 5274167 (1993-12-01), Lange et al.
patent: 5702710 (1997-12-01), Charpentier et al.
patent: 0709382 (1996-01-01), None
patent: 9604284 (1996-02-01), None
patent: 9708161 (1997-06-01), None
Adams C. Synthetic Communications, 1984, 14(10): 955-9.
Gribble GW and Nutaitis CF. Organic Preparations and Procedures International (1985), 17(4-5), 317-320.
Baldwin Jr., A. S., “The NF-κB and IκB Proteins: New Discoveries and Insights”, Annu. Rev. Immunol., 14: 649-681 (1996).
Barnes, P. J.; Adcock, I. M., “NF-κB: A Pivotal Role in Asthma and a New Target for Therapy”, TIPS, 18: 46-50 (Feb. 1997).
Baeuerle, P. A.; Henkel, T., “Function an Activation of NF-κB in the Immune System”, Annu. Rev. Immunol., 12: 141-179 (1994).
Cui, B.; Chai, H.; Santisuk, T.; Reutrakul, V.; Farnsworth, N. R.; Cordell, G. A.; Pezzuto, J. M.; Kinghorn, A. D., “Novel Cytotoxic 1H-Cyclopenta[b]benzofuran Ligans fromAglaia elliptica”, Tetrahedron, 53(52): 17625-17632 (1997).
Davey, A. E.; Schaeffer, M. J.; Taylor, R. J. K., “Synthesis of the Novel Anti-leukaemic Tetrahydrocyclopenta[b]benzofuran, Rocalamide and Related Synthetic Studies”, J. Chem. Soc. Perkin Trans. 1, pp. 1657-2665 (1992).
Davey, A. E., Schaeffer, M. J., and Taylor, R. J. K., “Synthesis of the Novel Anti-leukaemic Tetrahydrocyclopenta[b]benzofuran, Rocaglamide”, J. Chem. Soc. Commun., pp. 1137-1139 (1991).
Dumontet, V., Thoison, O., Omobuwajo, O. R., Martin, M.-T., Perromat, G., Chiaroni, A., Riche, C., Pais, M., and Sevenet, T., “New Nitrogenous and Aromatic Derivatives fromAglaia argenteaandA. forbesii”, Tetrahedron 52(20): 6931-6942 (1996).
Dieter Von, A.; Bömer, B.; Grosser, R.; Lange, W., “Neue Chirale Stationäre Polyamid-Phasen für die Chromatographische Enantiomerentrennung”, Angew. Chem., 103(12): 1685-1687 (1991).
Goldfeld, A. E.; Doyle, C.; Maniatis, T., “Human Tumor Necrosis Factor α Gene Regulation by Virus and Lipopolysaccharide”, Proc. Natl. Acad. Sci. USA, 87: 9769-9773.
Güssregen, B.; Fuhr, M.; Nugroho, B. W.; Wray, V.; Witte, L.; Proksch, P., “New Insecticidal Rocaglamide Derivatives from Flowers ofAglaia odorata”, Z. Naturforsch., C: Biosci., 52(5/6): 339-344 (1997).
Ishibashi, F.; Satasook, C.; Isman, M. B.; Towers, G. H. N., “Insecticidal 1H-Cyclopentatetrahydro[b]benzofurans from Aglaia odorata”, Phytochemistry, 32(2): 307-310 (1993).
Lenardo, M.J.; Baltimore, D., “NF-κB: a Pleiotropic Mediator of Inducible and Tissue-Specific Gene Control”, Cell, 58: 227-229 (1989).
Loveys, B.; Milborrow, B. V., “Hydroxylation of Methyl Abscisate and the Formation of Three β-D-Glucosides”, Phytochemistry, 31(1): 67-72 (1992).
Lu King, M.; Chiang, C.-C.; Ling, H.-C.; Fujita, E.; Ochiai, M.; McPhail, A. T., “X-Ray Crystal Structure of Rocaglamide, a Novel Antileukemic 1H-Cyclopenta[b]benzofuran fromAglaia elliptifolia”, J. Chem. Soc., Chem. Commun., pp. 1150-1151 (1982).
Nugroho, B. W.; Edrada, R. A.; Güssregen, B.; Wray, V.; Witte, L.; Proksch, P., “Insecticidal Rocaglamide Derivatives fromAglaia Duppereana”, Phytochemistry, 44(8): 1455-1461 (1997).
Oeth, P.; Parry, G. C. N.; Mackman, N., “Regulation of the Tissue Factor Gene in Human Monocytic Cells. Role of AP-1, NF-κB/Rel, and Sp1 Proteins in Uninduced and Lipopolysacharide-Induced Expression”, Arteriosclerosis, Thrombosis, and Vascular Biology, 17(2): 365-374 (Feb. 1997).
Ohse, T.; Ohba, S.; Yamamoto, T.; Koyano, T.; Umezawa, K., “Cyclopentabenzofuran Lignan Protein Synthesis Inhibitors fromAglaia odorata”, J. Nat. Prod., 59: 650-652 (1996).
Read, M. A.; Whitley, M. Z.; Gupta, S.; Pierce, J. W.; Best, J.; Davis, R. J.; Collins, T., “Tumor Necrosis Factor α-Induced E-Selectin Expression is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways”, J. Biol. Chem., 272(5): 2753-2761 (Jan. 1997).
Satasook, C.; Isman, M. B.; Wiriyachitra, P., “Activity of Rocaglamide, an Insecticidal Natural Product, Against the Variegated Cutworm,Peridroma saucia(Lepidoptera: Noctuidae)”, Pestic. Sci., 36: 53-58 (1992).
Transfection of Mammalian Cells in Culture, L. G. Davis et al., Basic Methods in Molecular Biology, Elsevier Sci. Publishing Co., New York (1986).
Greene, T. W.; Wuts, P. G. M., Protective Groups in Organic Synthesis, 2ndEd., John Wiley & Sons, New York (1991).

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