Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1976-12-17
1978-03-07
Gallagher, R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
260295F, 260295R, 2602955B, 260463, 260563R, 260563P, 2605705CA, 2605709, 424311, 424314, 424325, 424330, 560252, 560228, 560 38, 560173, 560220, 560105, 560106, A61K 31455, C07D21302, C07D21390
Patent
active
040780660
ABSTRACT:
The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## WHEREIN (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5', R.sup.5 and R.sup.6 may be the same or different and may be the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino;
R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; radical of 1-6 carbon atoms;
R.sup.7 and R.sup.8 may be the same or different and may be hydrogen or alkyl, and R.sup.7 and R.sup.8 taken together with the carbon atoms bearing substituents OR.sup.2 and OR.sup.4 may form a cycloalkyl ring. These compounds have been found useful in the treatment of hypertension in mammalian species, as surface active agents, as in vivo antibacterial compounds and as water softeners.
REFERENCES:
patent: 3936465 (1976-02-01), Hauck et al.
patent: 4022788 (1977-05-01), Hauck et al.
Hauck Frederic Peter
Sundeen Joseph E.
E. R. Squibb & Sons Inc.
Gallagher R.
Levinson Lawrence S.
Rodney Burton
Smith Merle J.
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