Cyclohexadiene derivatives useful in the treatment of depression

Details Cyclohexadiene derivatives useful in the treatment of depression Cyclohexadiene derivatives useful in the treatment of depression

1996-03-27

1997-07-29

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514535, 514344, 514345, 514352, A61K 31235, A61K 3124, A61K 3144

Patent

active

056522649

ABSTRACT:
The cyclohexadiene derivatives are prepared by reaction of cyclohexanones with amines and subsequent dehydration. The compounds are effective in the treatment of depression on account of their property of being selective modulators of calcium channel-dependent potassium channels.

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P. Tas et al., Neuroscience Letters, vol. 94, pp. 279-284, (1988).
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A. San Feliciano et al, Tetrahedron, vol. 47, No. 32, pp. 6503-6510 (1991).
Patent Abstracts of Japan, vol. 14, No. 123, (C-0698), Abstract of JP 02-129 (1990).

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