Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-10-15
1998-05-12
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514381, 514529, 514530, 514532, 514619, 514620, 514716, 514717, 514730, 514731, 548143, 548250, 548251, 548252, 548253, 548254, 560 38, 560 39, 560 43, 564164, 564163, 564168, A61K 3141, C07D25704, C07D27110
Patent
active
057505497
ABSTRACT:
The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, R.sup.13, A, Q, W, X, Y, Z and n are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.
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Chemical Abstracts, vol. 64, No. 8, Apr. 11, 1966, Abstract pp. 12732-12733 .
Caldwell Charles G.
Chen Ping
Durette Philippe L.
Finke Paul
Hale Jeffrey
McKane Joseph
Merck & Co. , Inc.
Rose David L.
Thies J. Eric
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