Cycloalkyl, lactam, lactone and related compounds,...

Details Cycloalkyl, lactam, lactone and related compounds,... Cycloalkyl, lactam, lactone and related compounds,...

2005-10-04

2005-10-04

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S221000

Reexamination Certificate

active

06951854

ABSTRACT:
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

REFERENCES:
patent: 2938029 (1960-05-01), Brenner et al.
patent: 3598859 (1971-08-01), Yates et al.
patent: 3657341 (1972-04-01), Thorne et al.
patent: 4080449 (1978-03-01), Croisier et al.
patent: 4410520 (1983-10-01), Watthey
patent: 4460579 (1984-07-01), Karenewsky
patent: 4473575 (1984-09-01), Watthey
patent: 4477464 (1984-10-01), Slade et al.
patent: 4666829 (1987-05-01), Young et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 4997168 (1991-03-01), Kato
patent: 5015639 (1991-05-01), Berger et al.
patent: 5206235 (1993-04-01), Fisher et al.
patent: 5238932 (1993-08-01), Flynn et al.
patent: 5247080 (1993-09-01), Berger et al.
patent: 5283241 (1994-02-01), Bochis et al.
patent: 5284841 (1994-02-01), Chu et al.
patent: 5324726 (1994-06-01), Bock et al.
patent: 5360802 (1994-11-01), Chambers et al.
patent: 5420271 (1995-05-01), Warchawsky et al.
patent: 5424425 (1995-06-01), Flynn et al.
patent: 5430145 (1995-07-01), Flynn et al.
patent: 5457196 (1995-10-01), Warshawsky et al.
patent: 5478857 (1995-12-01), Clemens et al.
patent: 5484783 (1996-01-01), Flynn et al.
patent: 5486513 (1996-01-01), Warshawsky et al.
patent: 5486541 (1996-01-01), Sterling et al.
patent: 5502048 (1996-03-01), Chapdelaine et al.
patent: 5519061 (1996-05-01), Youdim et al.
patent: 5532415 (1996-07-01), Youdim et al.
patent: 5545735 (1996-08-01), Bochis et al.
patent: 5556969 (1996-09-01), Chambers et al.
patent: 5629309 (1997-05-01), Flynn et al.
patent: 5633251 (1997-05-01), Claremon et al.
patent: 5646276 (1997-07-01), Robl
patent: 5650408 (1997-07-01), Karanewsky et al.
patent: 5656626 (1997-08-01), Chapdelaine et al.
patent: 5658901 (1997-08-01), Claremon et al.
patent: 5672598 (1997-09-01), De et al.
patent: 5679671 (1997-10-01), Oinuma et al.
patent: 5712397 (1998-01-01), Esser et al.
patent: 5770573 (1998-06-01), Arrhenius et al.
patent: 1 063 108 (1979-09-01), None
patent: 0 061 187 (1982-09-01), None
patent: 0 167 919 (1986-01-01), None
patent: 0 284 256 (1988-09-01), None
patent: 0 349 949 (1990-01-01), None
patent: 0 376 849 (1990-07-01), None
patent: 0 434 360 (1991-06-01), None
patent: 0 434 364 (1991-06-01), None
patent: 0 434 369 (1991-06-01), None
patent: 0 490 590 (1992-06-01), None
patent: 0 514 133 (1992-11-01), None
patent: 0 523 845 (1993-01-01), None
patent: 0 549 039 (1993-06-01), None
patent: 0591529 (1994-04-01), None
patent: 0 647 632 (1995-04-01), None
patent: 0 652 009 (1995-05-01), None
patent: 0 652 009 (1995-06-01), None
patent: 0 652 009 (1995-06-01), None
patent: 0 667 344 (1995-08-01), None
patent: 0 677 517 (1995-10-01), None
patent: 0 677 517 (1995-10-01), None
patent: 0 732 399 (1996-09-01), None
patent: 0 732 399 (1996-09-01), None
patent: 0 778 266 (1997-06-01), None
patent: 0 788 266 (1997-06-01), None
patent: 0 778 266 (1997-11-01), None
patent: 0 778 266 (1997-11-01), None
patent: 810221 (1997-12-01), None
patent: 0945445 (1999-09-01), None
patent: 1 519 931 (1977-01-01), None
patent: 1519495 (1978-07-01), None
patent: 1 519 495 (1978-07-01), None
patent: 1 519 931 (1978-07-01), None
patent: 1 573 931 (1980-08-01), None
patent: 2 272 439 (1994-05-01), None
patent: 2 290 788 (1996-01-01), None
patent: 2 290 788 (1996-01-01), None
patent: 71515 (1995-12-01), None
patent: 5247033 (1993-09-01), None
patent: 06145148 (1994-05-01), None
patent: 06145148 (1994-05-01), None
patent: 04210967 (1994-08-01), None
patent: 04210967 (1994-08-01), None
patent: 6211812 (1994-08-01), None
patent: 07304770 (1995-11-01), None
patent: 07304770 (1995-11-01), None
patent: 10072444 (1998-03-01), None
patent: 10072444 (1998-03-01), None
patent: 179757 (1998-04-01), None
patent: 10101560 (1998-04-01), None
patent: WO92/01683 (1992-02-01), None
patent: WO 92/11246 (1992-07-01), None
patent: WO92/16524 (1992-10-01), None
patent: WO93/19052 (1993-09-01), None
patent: WO93/19063 (1993-09-01), None
patent: WO 94/00438 (1994-01-01), None
patent: WO94/04531 (1994-03-01), None
patent: WO94/05693 (1994-03-01), None
patent: 95/04531 (1994-03-01), None
patent: WO94/07486 (1994-04-01), None
patent: WO94/10569 (1994-11-01), None
patent: WO 94/25445 (1994-11-01), None
patent: WO 95/03285 (1995-02-01), None
patent: WO95/03289 (1995-02-01), None
patent: WO95/03290 (1995-02-01), None
patent: WO95/09838 (1995-04-01), None
patent: WO95/14671 (1995-06-01), None
patent: WO95/21840 (1995-08-01), None
patent: WO 95/25117 (1995-09-01), None
patent: WO95/25118 (1995-09-01), None
patent: WO95/23810 (1995-10-01), None
patent: WO95/32191 (1995-11-01), None
patent: WO96/05839 (1996-02-01), None
patent: WO96/16981 (1996-06-01), None
patent: WO96/19492 (1996-06-01), None
patent: WO96/20725 (1996-07-01), None
patent: WO96/22966 (1996-08-01), None
patent: WO 96/25408 (1996-08-01), None
patent: WO 96/29313 (1996-09-01), None
patent: WO96/40146 (1996-12-01), None
patent: WO96/40653 (1996-12-01), None
patent: WO96/40654 (1996-12-01), None
patent: WO96/40655 (1996-12-01), None
patent: WO96/40656 (1996-12-01), None
patent: WO 97/16410 (1997-05-01), None
patent: WO97/30072 (1997-08-01), None
patent: WO 97/38705 (1997-10-01), None
patent: WO98/00405 (1998-01-01), None
patent: WO 98/04539 (1998-02-01), None
patent: WO 98/22430 (1998-05-01), None
patent: WO 98/22433 (1998-05-01), None
patent: WO 98/22494 (1998-05-01), None
patent: WO 98/25911 (1998-06-01), None
patent: WO98/25930 (1998-06-01), None
patent: WO98/28268 (1998-07-01), None
patent: WO 98/38177 (1998-09-01), None
patent: WO98/38177 (1998-09-01), None
Bock, et al., “Selective Non-Peptide Ligands for an Accommodating Peptide Receptor. Imidazobenzodiazepines as Potent Cholecystokinin Type B Receptor Antagonists”, Bioorg. and Med. Chem. Lets. 2(9):987-998 (1994).
Bock, et al., “An Expedient Synthesis of 3-Amino-1,3-Dihydro-5-Phenyl-2H-1,4-Benzodiazepin-2-one”, Tet. Lets., 28(9):939-942 (1987).
Evans, et al., “Molecular Mimicry and the Design of Peptidomimetrics”, Molecular Mimicry in Health and Disease, [A. Lernmark, et al, eds.], Elsevier Science Publishers B.V. (Biomedical Division) (1988).
Hofmann, et al., “Interactions of Benzodiazepine Derivatives with Annexins”, J. Biol. Chem., 273(5):2885-2894 (1998).
Evans, et al., “Methods for Drug Discovery: Development of Potent, Selective, Orally Effective Cholecystokinin Antagonists”, J. Med. Chem., 31:2235-2246 (1988).
Bock, et al, “Synthesis and Resolution of 3-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones”, J. Org. Chem., 52:3232-3239 (1987).
Lowe, et al., “5-Phenyl-3-ureidobenzazepin-2-ones as Cholecystokinin-B Receptor Antagonists”, J. Med. Chem., 37:3789-3811 (1994).
Chambers, et al., “L-708,474: The C5-Cyclohexyl Analogue of L-365,260, A Selective High Affinity Ligand for the CCKB/Gastrin Receptor”, Bioorg. and Med. Chem. Lets., 3(10):1919-1924 (1993).
Lowe, et al., “A Water Soluble Benzazepine Cholecystokinin-B Receptor Antagonist”, Bioorg. and Med. Chem. Lets., 5(17):1933-1936 (1995).
Rittle, et al., “A New Amine Resolution Method and Its Application to 3-Aminobenzodiazepines”, Tet. Lets., 28(5):521-522 (1987).
Satoh, et al., “New, 1,4-Benzodiazepin-2-one Derivatives as Gastrin/Cholecystokinin-B Antagonists”, Chem. Pharm. Bull., 43(12):2159-2167 (1995).
Hirst, et al., “Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity (II): Optimization of the C3 Amino Substituent”, J. Med. Chem., 39:5236-5245 (1996).
Smith, et al., “β-APP Processing as a Therapeutic Target for Alzheimer's Disease”, Current Pharmaceutical Design, 3:439-445 (1997).
Cordell, “

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