Cyclic β-amino acid derivatives as inhibitors of...

Details Cyclic β-amino acid derivatives as inhibitors of... Cyclic β-amino acid derivatives as inhibitors of...

2006-01-10

2006-01-10

Tsang, Cecilia J. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S127000, C546S166000, C546S135000, C546S194000, C514S318000

Reexamination Certificate

active

06984648

ABSTRACT:
The present application describes novel cyclic β-amino acid derivatives of formula I:or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease and/or as TNF-α inhibitors.

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Mohamed, M. M. et al. “Studies on the cyclization of the products of Stobbe condensation with 2,4-dimethylacetophenone”,Rev. Roum. Chim. (1981), 26(3), 441-8.

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