Cyclic peptides and use thereof

Details Cyclic peptides and use thereof Cyclic peptides and use thereof

1994-04-20

1997-04-01

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530328, 530321, C07K 764

Patent

active

056166842

ABSTRACT:
Cyclic peptides and their salts have antagonistic activity on endothelin receptors and antagonistic activity on NK2 receptors. The peptides have the formula ##STR1## wherein X and Y each represent .alpha.-amino acid residues, A represents a D-acidic-.alpha.-amino acid residue, B represents a neutral .alpha.-amino acid residue, C represents an L-.alpha.-amino acid residue and D represents a D-.alpha.-amino acid residue having an aromatic ring group; wherein hydroxy, thiol, amino, imino and carboxyl groups can be substituted or unsubstituted. Pharmaceutical compositions containing such peptides are also described.

REFERENCES:
patent: 5114918 (1992-05-01), Ishikawa et al.
patent: 5260276 (1993-11-01), Cody et al.
Japanese Patent Unexamined Publication No. 3-94692/91.
Japanese Patent Unexamined Publication No. 3-130299/91.
Japanese Patent Unexamined Publication No. 3-17098/91.
Japanese Patent Unexamined Publication No. 3-141295/91.
Editors: Smith et al., "Peptides - Proceedings of the 12th American Peptide Proceedings of the 12th American Peptide Symposium", Jun. 1991, Cambridge, USA' 1992, Escom, Leiden, Holland & Ishikawa, et al., Endothelin antagonistic cyclic pentapeptides with high selectivity for ETa receptor; pp. 812-813.
Masaki Ihara et al.; Biochemical and Biophysical Research Communications, vol. 178, No. 1, 1991 pp. 132-137, Jul. 15, 1991 "An Endothelin Receptor (ET.sub.A) Antagonist Isolated From Streptomyces Misakiensis".
K. Ishikawa et al.; Peptides, Chemistry and Biology, pp. 812-813, Jun. 16-21, 1991, "Endothelin antagonistic cyclic pentapeptides with high selectivity for ET.sub.A receptor".
Himata et al, Biochem. and Biophys. Research Commun., vol. 160, pp. 228-234, (Apr. 14, 1989).
Ihara et al, Life Sciences, vol. 50, pp. 247-255, (1991).
Nakajima et al, Biochem. and Biophys. Research Commun., vol. 163(1), (Aug. 30, 1989), pp. 424-429.
Kimura et al, Biochem. and Biophys. Research Commun., vol. 156(3), (Nov. 15, 1988), pp. 1182-1186.
Doherty, Journal of Medicinal Chemistry, vol. 35(9), pp. 1493-1508, (1992).
Saeki et al, Biochemical and Biophysical Res. Comm., vol. 179, No. 1, pp. 286-292, (Aug. 30, 1991).

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