snRNP-A antigen and fragments thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

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Details

530327, 530328, 4241851, 435 693, C07K 752, C07K 900, A61K 3900

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active

056166850

ABSTRACT:
The present invention relates to a protein antigen which is reactive towards an auto-antibody which is associated with an auto-immune disease, and the use of this protein in diagnostic tests relating to auto-immune diseases.

REFERENCES:
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patent: 4394443 (1983-07-01), Weissman et al.
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I. Pettersson et al., "The Structure of Mammalian Small Nuclear Ribonucleoproteins", The Journal of Biological Chemistry, vol. 259, No. 9, pp. 5907-5914, May 10, 1984, USA.
P. Bringmann et al., "Purification of the Individual snRNPs U1, U2, U5 and U4/U6 from HeLa Cells and Characterization of their Protein Constituents", The Embo Journal, vol. 5, No. 13, pp. 3509-3516, 1986, Great Britain.
P. Bringmann et al., "Purification of snRNPs U1, U2, U4, U5 and U6 with 2,2,7-trimethylguanosine-specific antibody and definition of their constituent proteins reacting with anti-Sm and anti-(U1) RNP antisera", The EMBO Journal, vol. 2, No. 7, pp. 1129-1135, 1983, Great Britain.
Laemmli, U.K., Nature, 227:680-685, 1970.

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