Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-06-29
1993-10-12
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
544142, 548433, 548451, 548477, A61K 3702, C07D20966, C07D41312
Patent
active
052525600
ABSTRACT:
Compounds are described of the formula ##STR1## wherein: R.sup.1 is C.sub.3-6 alkyl or C.sub.1-3 alkylthioC.sub.1-3 alkyl;
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Chantry, et al, "Metalloendoprotease Cleavage of 18.2- and 14.1-Kilodalton Basic Proteins Dissociating from Rodent Myelin Membranes Generates 10.0- and 5.9-Kilodalton C-Terminal Fragments", J. Neurochem, 50, No. 3, 688-694 (1988).
Gravallese, et al, "In Situ Hybridization Studies Of Stromelysim and Collagen Messenger RNA Expression in Rheumatoid Synovium", Arthritis and Rheumatism, 34, No. 9, 1076-1084 (1991).
Wooley, et al, "Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint" Arthritis and Rheumatism, 20, No. 6, 1231-1239 (1977).
Brown Peter J.
Davies Howard G.
Drewry David H.
Foley Michael A.
Gregson Michael
Glaxo Inc.
Levy David J.
Ramsuer Robert W.
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