Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materi

Details Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materi Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materi

1995-06-07

1997-07-29

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

536 231, 536 232, 536 235, 435 691, 4353201, 4351723, 4352523, 435325, 435 701, 435 703, 435 711, 435 712, 43525233, 4352542, 435365, 935 3, 935 14, 935 27, 935 28, 935 29, 935 56, 935 69, 935 70, 935 72, 935 73, C12N 1555, C12N 916, C12N 1563, C12N 121

Patent

active

056521316

ABSTRACT:
The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.

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