Cyclic endothelin antagonists

Details Cyclic endothelin antagonists Cyclic endothelin antagonists

1996-07-09

1999-03-16

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 514 2, 530317, 530321, A61K 3012, C07K 764

Patent

active

058830758

ABSTRACT:
Disclosed are (1) a cyclic hexapeptide represented by formula I or a salt thereof: ##STR1## wherein X and Y each represent .alpha.-amino acid residues, A represents a D-acidic-.alpha.-amino acid residue, B represents a neutral-.alpha.-amino acid residue, C represents an L-.alpha.-amino acid residue and D represents a D-.alpha.-amino acid residue having an aromatic ring group; and (2) a pharmaceutical composition comprising the peptide represented by formula I or a pharmaceutically aceptable salt thereof as an active ingredient.

REFERENCES:
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patent: 5260276 (1993-11-01), Cody et al.
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Watanabe, et al., "Contribution of Endogeneous Endothelin to the Extension of Myocardial Infarct Size in Rats", Circulation Research, vol. 69, NO. 2, Aug. 1991, pp. 370-377.
M. Ihara et al., "An Endothelin Receptor (ET.sub.A) Antagonist isolated from Streptomyces Misakiensis." Editors: Abelson et al., Biochemical and Biophysical Research Communications, vol. 178, No. 1, Academic Press, Inc., 1991, pp. 132-137.

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