Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Reexamination Certificate
2007-10-23
2007-10-23
Steadman, David J. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Reexamination Certificate
active
10070387
ABSTRACT:
The present invention provides an enzyme that synthesizes a cyclic depsipeptide, particularly the substance 1022, and a gene thereof. A cyclic depsipeptide synthetase according to the present invention comprises (a) an amino acid sequence of SEQ ID NO: 2 or (b) a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that have one or more modifications selected from a substitution, a deletion, an addition and an insertion and has cyclic depsipeptide synthetase activity. A cyclic depsipeptide synthetase gene according to the present invention comprises a nucleotide sequence encoding a cyclic depsipeptide synthetase. The present invention also provides a recombinant vector and a transformant for expressing the cyclic depsipeptide synthetase, and a mass production system for the cyclic depsipeptide. The present invention further provides a method for producing the cyclic depsipeptide synthetase.
REFERENCES:
patent: 5763221 (1998-06-01), Aoyagi et al.
patent: 6057491 (2000-05-01), Cigan et al.
patent: 382173 (1990-08-01), None
patent: 0 578 616 (1994-12-01), None
patent: 780468 (1997-06-01), None
Lawen et al. (1990) J Biol Chem 265:11355-11360.
Branden et al. “Introduction to Protein Structure”, Garland Publishing Inc. New York, 1991.
Witkowski et al. (1999) Biochemistry 38:11643-11650.
Matsudaira (1990) Methods Enzymol 182:602-613.
Wozney (1990) Methods Enzymol 182:738-751.
Database GenBank Accesssion No. S39842, Dec. 1993.
Seffernick et al. (1999) J Bacteriol 183:2405-2410.
Broun et al. (1998) Science 282:1315-1317.
Guo et al. (2004) Proc Natl Acad Sci 101:9205-9210.
Hult et al. (2003) Curr Opin Biotechnol 14:395-400.
M Marahiel et al., “Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis”, Chemical Reviews, American Chemical Society, vol. 97, No. 7, Nov. 1997, pp. 2651-2673.
J. Burmester et al., “Highly Conserved N-Methyltransferases as an Integral part of Peptide Synthetases”, Biochemistry and Molecular Biology International, vol. 37, No. 2, Oct. 1995, pp. 201-207.
Weckwerth, Wolfram et al., “Biosynthesis of PF1022A and Related Cyclooctadepsipeptides”, The Journal of Biological Chemistry, Jun. 9, 2000, vol. 275, No. 23 pp. 17909-17915.
Haese, Angela et al., “Molecular characterization of the enniatin synthetase gene encoding a multifunctional enzyme catalysing N-methyldepsipeptide formation inFusarium scirpi”, Molecular Microbiology, Mar. 1993, vol. 7, No. 6, pp. 905-914.
Sasaki, Toru et al., “A new anthelmintic cyclodepsipeptide, PF1022A”, The Journal of Anitbiotics, May 25, 1992, vol. 45, No. 5, pp. 692-697.
Aihara Sato
Futamura Takafumi
Kleinkauf Horst
Midoh Naoki
Miyamoto Koichi
Meiji Seika Kaisha Ltd.
Steadman David J.
Wenderoth , Lind & Ponack, L.L.P.
LandOfFree
Cyclic depsipeptide synthetase and method for recombinant... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclic depsipeptide synthetase and method for recombinant..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic depsipeptide synthetase and method for recombinant... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3890982