Cyclic depsipeptide PF 1022G

Details Cyclic depsipeptide PF 1022G Cyclic depsipeptide PF 1022G

2000-02-16

2000-11-14

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

530317, 530323, 530328, 514 9, 514 11, A61K 3812, C07K 1600, C12P 2104

Patent

active

061468533

ABSTRACT:
Known cyclic depsipeptides which are PF 1022F substance and PF 1022H substance, as well as a novel cyclic depsipeptide, PF 1022G substance, are now prepared simultaneously by cultivating a fungal strain capable of producing PF 1022F substance, PF 1022G substance and PF 1022H substance represented by the known PF 1022 strain (deposited under FERM BP-2671) which is a kind of fungus belonging to asporous imperfect fungi (the order Agonomycetales) and is presumable to belong to the genus Xylaria or the genus Rosellinia in the family Xylariaceae. The PF 1022G substance has the formula: ##STR1##

REFERENCES:
patent: 5116815 (1992-05-01), Takagi et al.
patent: 5747448 (1998-05-01), Ohyama et al.
Sasaki, T. et al., A New Anthelmintic Cyclodepsipeptide, PF 1022A, The Journal of Antibiotics, vol. 45, No. 5, pp. 692-697.

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