Cyclic amines

Details Cyclic amines Cyclic amines

2006-04-13

2010-10-26

Morris, Patricia L (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S278400, C546S279100

Reexamination Certificate

active

07820699

ABSTRACT:
The invention is concerned with cyclic amines of formula (I)wherein X1to X3, Y1to Y3, R1′, R1″and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments and for treating diseases associated with coagulation factor Xa.

REFERENCES:
patent: WO 2004/087646 (2004-10-01), None
patent: WO 2005/032472 (2005-04-01), None
patent: WO 2006/012226 (2006-02-01), None
patent: WO 2006/032342 (2006-03-01), None
patent: WO 2006/066896 (2006-06-01), None
Balant et al., “Metabolic Considerations, etc.,” Burger's Medicinal Chemistry, 5th ed. , 1, Wolff ed. NY: John Wiley & Sons, 1995, pp. 949-982.
Schaus et al., J. Org. Chem., 62, pp. 4197-4199 (1997).
Bouzard et al., J. Med. Chem., 33, pp. 1344-1352 (1990).
Sarmiento et al., Tetrahedron Asymmetry, 14, pp. 1547-1551 (2003).
Lee et al., Bioorg. Med. Chem. Lett., 13, pp. 4399-4403 (2003).
Kim et al., J. Med. Chem., 40, pp. 3584-3593 (1997).
Hansen et al., Acta Chemica Scandinavica, 52, pp. 1214-1222 (1997).

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